The past, present, and future of immune repertoire biology–the rise of next-generation repertoire analysis
A Six, ME Mariotti-Ferrandiz, W Chaara… - Frontiers in …, 2013 - frontiersin.org
T and B cell repertoires are collections of lymphocytes, each characterized by its antigen-
specific receptor. We review here classical technologies and analysis strategies developed …
specific receptor. We review here classical technologies and analysis strategies developed …
Current status and recent advances of next generation sequencing techniques in immunological repertoire
XL Hou, L Wang, YL Ding, Q Xie, HY Diao - Genes & Immunity, 2016 - nature.com
To ward off a wide variety of pathogens, the human adaptive immune system harbors a vast
array of T-cell receptors (TCRs) and B-cell receptors (BCRs), collectively referred to as the …
array of T-cell receptors (TCRs) and B-cell receptors (BCRs), collectively referred to as the …
Tumor-infiltrating and peripheral blood T-cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma
Purpose: The efficacy of PD-1 checkpoint blockade as adjuvant therapy in localized clear
cell renal cell carcinoma (ccRCC) is currently unknown. The identification of tumor …
cell renal cell carcinoma (ccRCC) is currently unknown. The identification of tumor …
Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study …
D Wilkins, AC Langedijk, RJ Lebbink… - The Lancet Infectious …, 2023 - thelancet.com
Background Nirsevimab is an extended half-life monoclonal antibody to the respiratory
syncytial virus (RSV) fusion protein that has been developed to protect infants for an entire …
syncytial virus (RSV) fusion protein that has been developed to protect infants for an entire …
Tumor-and neoantigen-reactive T-cell receptors can be identified based on their frequency in fresh tumor
A Pasetto, A Gros, PF Robbins, DC Deniger… - Cancer immunology …, 2016 - AACR
Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-
specific antigens can mediate cancer regression. Accumulating evidence suggests that the …
specific antigens can mediate cancer regression. Accumulating evidence suggests that the …
Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms
PA Reche, EL Reinherz - Journal of molecular biology, 2003 - Elsevier
Major histocompatibility complex class I (MHCI) and class II (MHCII) molecules display
peptides on antigen-presenting cell surfaces for subsequent T-cell recognition. Within the …
peptides on antigen-presenting cell surfaces for subsequent T-cell recognition. Within the …
Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures
M Zemlin, M Klinger, J Link, C Zemlin, K Bauer… - Journal of molecular …, 2003 - Elsevier
Immunoglobulin junctional diversity is concentrated in the third complementarity-determining
region of the heavy chain (CDR-H3), which often plays a dominant role in antigen binding …
region of the heavy chain (CDR-H3), which often plays a dominant role in antigen binding …
Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles
PA Reche, JP Glutting, H Zhang, EL Reinherz - Immunogenetics, 2004 - Springer
We introduced previously an on-line resource, RANKPEP that uses position specific scoring
matrices (PSSMs) or profiles for the prediction of peptide-MHC class I (MHCI) binding as a …
matrices (PSSMs) or profiles for the prediction of peptide-MHC class I (MHCI) binding as a …
[HTML][HTML] T follicular helper and T follicular regulatory cells have different TCR specificity
Immunization leads to the formation of germinal centres (GCs) that contain both T follicular
helper (Tfh) and T follicular regulatory (Tfr) cells. Whether T-cell receptor (TCR) specificity …
helper (Tfh) and T follicular regulatory (Tfr) cells. Whether T-cell receptor (TCR) specificity …