The tandem β-zipper protein–protein binding interface involves an intrinsically disordered
protein (IDP) binding two or more globular domains through β-sheet-augmentation in a …

Islet 1 (Isl1) is a transcription factor of the LIM-homeodomain (LIM-HD) protein family and is
essential for many developmental processes. LIM-HD proteins all contain two protein …

Motor neuron (MN) progenitor cells rapidly induce high expression of the transcription
factors Islet-1 (Isl1), LIM-homeobox 3 (Lhx3), and the transcriptional regulator LMO4, as they …

LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in
embryonic development and breast cancer. It has been reported to bind many partners …

LIM-only protein 4 (LMO4) is strongly linked to the progression of breast cancer. Although
the mechanisms underlying this phenomenon are not well understood, a role is emerging for …

Abstract LIM-Homeodomain (LIM-HD) transcription factors are highly conserved in animals
where they are thought to act in a transcriptional 'LIM code'that specifies cell types …

Tandem beta zippers are modular complexes formed between repeated linear motifs and
tandemly arrayed domains of partner proteins in which β‐strands form upon binding. Studies …

Peptide aptamers of LIM-only protein 2 (Lmo2) were previously used to successfully treat
Lmo2-induced tumours in a mouse model of leukaemia. Here we show that the Lmo2 …

Dynamic changes in chromatin architecture underpin gene expression in development. The
chromatin integrator protein LDB1 is a key regulatory node in the organization of …

Coordinated series of large-scale transcriptional changes and chromatin reorganization
drive cell type specification and differentiation during embryogenesis. In this process …