Mitochondrial dynamics proteins as emerging drug targets

E Zacharioudakis, E Gavathiotis - Trends in pharmacological sciences, 2023 - cell.com
The importance of mitochondrial dynamics, the physiological process of mitochondrial fusion
and fission, in regulating diverse cellular functions and cellular fitness has been well …

Neurohormonal connections with mitochondria in cardiomyopathy and other diseases

GW Dorn 2nd - American Journal of Physiology-Cell …, 2022 - journals.physiology.org
Neurohormonal signaling and mitochondrial dynamism are seemingly distinct processes
that are almost ubiquitous among multicellular organisms. Both of these processes are …

Mitochondrial dysfunction and pharmacodynamics of mitofusin activation in murine Charcot-Marie-Tooth disease type 2A

A Franco, X Dang, L Zhang, PB Molinoff… - The Journal of …, 2022 - Elsevier
ABSTRACT Mitofusin (MFN) 1 and MFN2 are dynamin GTPase family mitochondrial proteins
that mediate mitochondrial fusion requiring MFN conformational shifts, formation of …

Activating mitofusins interrupts mitochondrial degeneration and delays disease progression in SOD1 mutant amyotrophic lateral sclerosis

X Dang, L Zhang, A Franco… - Human molecular …, 2023 - academic.oup.com
Mitochondrial involvement in neurodegenerative diseases is widespread and multifactorial.
Targeting mitochondrial pathology is therefore of interest. The recent development of …

Reversing Dysdynamism to Interrupt Mitochondrial Degeneration in Amyotrophic Lateral Sclerosis

GW Dorn - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis is one of several chronic neurodegenerative conditions in
which mitochondrial abnormalities are posited to contribute to disease progression …

Sensory-motor neuropathy in Mfn2 T105M knock-in mice and its reversal by a novel piperine-derived mitofusin activator

J Weigele, L Zhang, A Franco, E Cartier… - The Journal of …, 2024 - Elsevier
Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but
therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies …

Mitochondrial Dynamics as Potential Modulators of Hormonal Therapy Effectiveness in Males

A Errico, S Vinco, G Ambrosini, E Dalla Pozza… - Biology, 2023 - mdpi.com
Simple Summary Andrological diseases that affect patients in pediatric age represent
important risk factors for alterations of their fertile potential in adulthood, and hence early …

Piperine relieves neuropathic pain induced by paclitaxel in mice

T Sahranavard, V Ghorani, F Forouzanfar… - Acta Neurobiologiae …, 2024 - ane.pl
Piperine is an amide alkaloid isolated from the black pepper plant. This study examined the
pain‑relieving activity of piperine against paclitaxel (PTX)‑induced neuropathy. Male mice …

In silico identification and virtual screening to discover potent therapeutic phytochemicals against CMT2A

A Iqbal, HB Waseem, F Ali, S Baammi… - Journal of the Indian …, 2024 - Elsevier
Abstract Charcot-Marie-Tooth (CMT2A) neuropathies are a set of monogenic diseases that
affect the peripheral nervous system. The pathogenesis of CMT2A, a disease caused by …