Targeting mitochondria with ClpP agonists as a novel therapeutic opportunity in breast cancer

R Wedam, YE Greer, DJ Wisniewski, S Weltz, M Kundu… - Cancers, 2023 - mdpi.com
Simple Summary Mitochondria, often called “the powerhouse of the cell”, generate most of
the energy required for all cellular processes. Mitochondria also provide a platform for …

Updates on triple-negative breast cancer in type 2 diabetes mellitus patients: from risk factors to diagnosis, biomarkers and therapy

S Matou-Nasri, M Aldawood, F Alanazi, AL Khan - Diagnostics, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is usually the most malignant and aggressive
mammary epithelial tumor characterized by the lack of expression for estrogen receptors …

Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

B Cui, B He, Y Huang, C Wang, H Luo, J Lu, K Su… - Cell Death & …, 2023 - nature.com
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor
relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive …

Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer

K Wahi, N Freidman, Q Wang, M Devadason… - The EMBO …, 2024 - embopress.org
Triple-negative breast cancer (TNBC) metabolism and cell growth uniquely rely on
glutamine uptake by the transporter ASCT2. Despite previous data reporting cell growth …

Unlocking apoptosis in triple negative breast cancer: Harnessing “glutamine trap” to amplify the efficacy of lapatinib-loaded mixed micelles

R Ghadi, K Kuche, T Date, B Nallamothu… - Biomaterials …, 2024 - Elsevier
Certain aggressive cancers, such as triple-negative breast cancer (TNBC), heavily bank on
glutamine for their proliferation and survival. In this context, TNBC functions as a “glutamine …

PoRVA G9P [23] and G5P [7] infections differentially promote PEDV replication by reprogramming glutamine metabolism

H Liu, H Tian, P Hao, H Du, K Wang, Y Qiu, X Yin… - PLoS …, 2024 - journals.plos.org
PoRVA and PEDV coinfections are extremely common in clinical practice. Although
coinfections of PoRVA and PEDV are known to result in increased mortality, the underlying …

Screening and diagnosis of triple negative breast cancer based on rapid metabolic fingerprinting by conductive polymer spray ionization mass spectrometry and …

Y Song, Y Zhang, S Xie, X Song - Frontiers in Cell and …, 2022 - frontiersin.org
We present the use of conductive spray polymer ionization mass spectrometry (CPSI-MS)
combined with machine learning (ML) to rapidly gain the metabolic fingerprint from 1 μl …

A tale of three proteomes: visualizing protein and transcript abundance relationships in the Breast Cancer Proteome Portal

Z Li, NM Vacanti - Journal of Proteome Research, 2023 - ACS Publications
Molecular characterization is transforming research on novel therapeutics in breast cancer.
High-throughput methodologies are unbiased to hypotheses; thus, data produced are …

[HTML][HTML] The metabolic crosstalk between PIN1 and the tumour microenvironment

I Caligiuri, C Vincenzo, T Asano, V Kumar… - Seminars in Cancer …, 2023 - Elsevier
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a member of a family of
peptidyl-prolyl isomerases that specifically recognizes and binds phosphoproteins …

Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer

TJ Carneiro, ALM Batista de Carvalho… - Journal of Medicinal …, 2024 - ACS Publications
Cisplatin (cDDP) resistance is a matter of concern in triple-negative breast cancer
therapeutics. We measured the metabolic response of cDDP-sensitive (S) and-resistant (R) …