SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …
particular risk for severe disease and death in older adults and in adults with age-related …
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
I mmunosenescence and inflammaging: risk factors of severe COVID-19 in older people
Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …
that occur during the aging process. These changes named collectively as …
Aging of the immune system: focus on inflammation and vaccination
M Pinti, V Appay, J Campisi, D Frasca… - European journal of …, 2016 - Wiley Online Library
Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …
an increasingly long life span in the developed parts of our planet, and indeed reaching …
The impact of aging-induced gut microbiome dysbiosis on dendritic cells and lung diseases
Aging is an inevitable natural process that impacts every individual, and understanding its
effect on the gut microbiome and dendritic cell (DC) functionality in elderly subjects is …
effect on the gut microbiome and dendritic cell (DC) functionality in elderly subjects is …
Immunosenescence and inflamm-ageing in COVID-19
The destructive effects of coronavirus disease 2019 (COVID-19) on the elderly and people
with cardiovascular disease have been proven. New findings shed light on the role of aging …
with cardiovascular disease have been proven. New findings shed light on the role of aging …
Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human …
Y Jing, E Shaheen, RR Drake, N Chen… - Human immunology, 2009 - Elsevier
Dendritic cells (DC) are potent antigen-presenting cells that initiate and regulate T-cell
responses. In this study, the numbers and functional cytokine secretions of plasmacytoid and …
responses. In this study, the numbers and functional cytokine secretions of plasmacytoid and …
Impact of aging on dendritic cell functions in humans
A Agrawal, S Gupta - Ageing research reviews, 2011 - Elsevier
Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central
orchestrators of the immune response with a key role in the generation of immunity and …
orchestrators of the immune response with a key role in the generation of immunity and …
Immunotherapy comes of age: immune aging & checkpoint inhibitors
R Elias, T Karantanos, E Sira, KL Hartshorn - Journal of geriatric oncology, 2017 - Elsevier
Immune checkpoint inhibitors (ICIs) are based on the understanding that there are
multilayered checks and balances which can be manipulated to unleash already existing …
multilayered checks and balances which can be manipulated to unleash already existing …
Immunomodulatory and antiaging mechanisms of resveratrol, rapamycin, and metformin: focus on mTOR and AMPK signaling networks
Aging results from the progressive dysregulation of several molecular pathways and mTOR
and AMPK signaling have been suggested to play a role in the complex changes in key …
and AMPK signaling have been suggested to play a role in the complex changes in key …