Degeneration of neurons and circuits across the striatum shows stereotyped time-course
and spatial topography patterns that are distinct for Huntington's disease, Parkinson's …

Intracerebral vector delivery in nonhuman primates has been a major challenge. We report
successful blood-brain barrier opening and focal delivery of adeno-associated virus …

The human brain has evolved unique capabilities compared to other vertebrates. The
mechanistic basis of these derived traits remains a fundamental question in biology due to …

The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta
(SNc) is a critical and unresolved question in Parkinson´ s disease. Studies in mice show …

Deciphering the striatal interneuron diversity is key to understanding the basal ganglia
circuit and to untangling the complex neurological and psychiatric diseases affecting this …

Exercise has been proposed as an effective non-pharmacological management for
Parkinson's disease (PD) patients. Irisin, a recently identified myokine, is increased by …

The interpretation of massive high-throughput gene expression data requires computational
and biological analyses to identify statistically and biologically significant differences …

The expansion of human and non-human primate central nervous system structures has
been a paramount question for classic and contemporary studies in comparative vertebrate …

Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc)
degenerate prominently in Parkinson's disease (PD), while those in the dorsal tier and …

Mesial temporal lobe epilepsy (MTLE) is one of the most common refractory epilepsies and
is usually accompanied by a range of brain pathological changes, such as neuronal injury …