The impact of microgravity on bone in humans

D Grimm, J Grosse, M Wehland, V Mann, JE Reseland… - Bone, 2016 - Elsevier
Experiencing real weightlessness in space is a dream for many of us who are interested in
space research. Although space traveling fascinates us, it can cause both short-term and …

The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Growing tissues in real and simulated microgravity: new methods for tissue engineering

D Grimm, M Wehland, J Pietsch… - … Engineering Part B …, 2014 - liebertpub.com
Tissue engineering in simulated (s-) and real microgravity (r-μ g) is currently a topic in Space
medicine contributing to biomedical sciences and their applications on Earth. The principal …

Using space-based investigations to inform cancer research on Earth

JL Becker, GR Souza - Nature Reviews Cancer, 2013 - nature.com
Experiments conducted in the microgravity environment of space are not typically at the
forefront of the mind of a cancer biologist. However, space provides physical conditions that …

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells

MZ Nassef, S Kopp, M Wehland, D Melnik… - International journal of …, 2019 - mdpi.com
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging

TJ Corydon, S Kopp, M Wehland, M Braun, A Schütte… - Scientific reports, 2016 - nature.com
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …

Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space

X Ma, J Pietsch, M Wehland, H Schulz… - The FASEB …, 2014 - Wiley Online Library
This study focuses on the effects of short‐term [22 s, parabolic flight campaign (PFC)] and
long‐term (10 d, Shenzhou 8 space mission) real microgravity on changes in cytokine …

Tissue engineering under microgravity conditions–use of stem cells and specialized cells

D Grimm, M Egli, M Krüger, S Riwaldt… - Stem Cells and …, 2018 - liebertpub.com
Experimental cell research studying three-dimensional (3D) tissues in space and on Earth
using new techniques to simulate microgravity is currently a hot topic in Gravitational Biology …

The impact of simulated and real microgravity on bone cells and mesenchymal stem cells

C Ulbrich, M Wehland, J Pietsch… - BioMed research …, 2014 - Wiley Online Library
How microgravity affects the biology of human cells and the formation of 3D cell cultures in
real and simulated microgravity (r‐and s‐µg) is currently a hot topic in biomedicine. In r‐and …