Cognitive dysfunction: a growing link between diabetes and Alzheimer's disease
K Jash, P Gondaliya, P Kirave… - Drug development …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting
millions of people worldwide. Diabetes is associated with various complications like …
millions of people worldwide. Diabetes is associated with various complications like …
JAK/STAT signaling in diabetic kidney disease
Y Liu, W Wang, J Zhang, S Gao, T Xu… - Frontiers in Cell and …, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes
and the leading cause of end-stage renal disease (ESRD) worldwide. The Janus …
and the leading cause of end-stage renal disease (ESRD) worldwide. The Janus …
[HTML][HTML] Metformin suppresses LRG1 and TGFβ1/ALK1-induced angiogenesis and protects against ultrastructural changes in rat diabetic nephropathy
HMF Mohammad, SG Gouda, MA Eladl… - Biomedicine & …, 2023 - Elsevier
Diabetic nephropathy (DN) has high prevalence and poor prognosis which make it a
research priority for scientists. Since metformin, a hypoglycaemic drug, has been found to …
research priority for scientists. Since metformin, a hypoglycaemic drug, has been found to …
Nifuroxazide ameliorates pulmonary fibrosis by blocking myofibroblast genesis: a drug repurposing study
C Gan, Q Zhang, H Liu, G Wang, L Wang, Y Li… - Respiratory …, 2022 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a serious interstitial lung disease with a
complex pathogenesis and high mortality. The development of new drugs is time-consuming …
complex pathogenesis and high mortality. The development of new drugs is time-consuming …
Nifuroxazide suppresses UUO-induced renal fibrosis in rats via inhibiting STAT-3/NF-κB signaling, oxidative stress and inflammation
NME Hassan, E Said, GSG Shehatou - Life Sciences, 2021 - Elsevier
The current work explored the influences of nifuroxazide, an in vivo inhibitor of signal
transducer and activator of transcription-3 (STAT-3) activation, on tubulointerstitial fibrosis in …
transducer and activator of transcription-3 (STAT-3) activation, on tubulointerstitial fibrosis in …
Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFκB balance and NLRP3 expression
The prevalence of diabetes mellitus (DM) drastically increases worldwide. Persistent
hyperglycemia affects body microvasculature causing injuries to kidney producing diabetic …
hyperglycemia affects body microvasculature causing injuries to kidney producing diabetic …
Pharmacological updates of nifuroxazide: promising preclinical effects and the underlying molecular mechanisms
Nifuroxazide (NFX) is a safe nitrofuran antibacterial drug used clinically to treat acute
diarrhea and infectious traveler diarrhea or colitis. Recent studies revealed that NFX …
diarrhea and infectious traveler diarrhea or colitis. Recent studies revealed that NFX …
Nifuroxazide attenuates indomethacin-induced renal injury by upregulating Nrf2/HO-1 and cytoglobin and suppressing NADPH-oxidase, NF-κB, and JAK-1/STAT3 …
EHM Hassanein, MA Abdel-Reheim… - Naunyn-Schmiedeberg's …, 2024 - Springer
Indomethacin (INDO) is an NSAID with remarkable efficacy and widespread utilization for
alleviating pain. Nevertheless, renal function impairment is an adverse reaction linked to …
alleviating pain. Nevertheless, renal function impairment is an adverse reaction linked to …
Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity
SY Alomar, BM Barakat, M Eldosoky, H Atef… - International …, 2021 - Elsevier
Microvascular complications of diabetes mellitus are progressively significant reasons for
mortality. Metformin (MET) is considered as the first-line therapy for type 2 diabetes patients …
mortality. Metformin (MET) is considered as the first-line therapy for type 2 diabetes patients …
The enteroprotective effect of nifuroxazide against methotrexate-induced intestinal injury involves co-activation of PPAR-γ, SIRT1, Nrf2, and suppression of NF-κB and …
EK Abd-Alhameed, AA Azouz, AM Abo-Youssef… - International …, 2024 - Elsevier
Methotrexate (MTX) has long manifested therapeutic efficacy in several neoplastic and
autoimmune disorders. However, MTX-associated intestinal toxicity restricts the continuation …
autoimmune disorders. However, MTX-associated intestinal toxicity restricts the continuation …