Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders
NJ Ashton, A Hye, AP Rajkumar, A Leuzy… - Nature Reviews …, 2020 - nature.com
Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …
18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases
Few studies have evaluated the relationship between in vivo 18F-flortaucipir PET and post-
mortem pathology. We sought to compare antemortem 18F-flortaucipir PET to …
mortem pathology. We sought to compare antemortem 18F-flortaucipir PET to …
Radiological biomarkers for diagnosis in PSP: where are we and where do we need to be?
JL Whitwell, GU Höglinger, A Antonini… - Movement …, 2017 - Wiley Online Library
ABSTRACT PSP is a pathologically defined neurodegenerative tauopathy with a variety of
clinical presentations including typical Richardson's syndrome and other variant PSP …
clinical presentations including typical Richardson's syndrome and other variant PSP …
18F‐flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study
Objective 18F‐flortaucipir (formerly 18F‐AV1451 or 18F‐T807) binds to neurofibrillary
tangles in Alzheimer disease, but tissue studies assessing binding to tau aggregates in …
tangles in Alzheimer disease, but tissue studies assessing binding to tau aggregates in …
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes
RM Tsai, A Bejanin, O Lesman-Segev, R LaJoie… - Alzheimer's research & …, 2019 - Springer
Background The tau positron emission tomography (PET) ligand 18 F-flortaucipir binds to
paired helical filaments of tau in aging and Alzheimer's disease (AD), but its utility in …
paired helical filaments of tau in aging and Alzheimer's disease (AD), but its utility in …
The tau positron‐emission tomography tracer AV‐1451 binds with similar affinities to tau fibrils and monoamine oxidases
C Vermeiren, P Motte, D Viot… - Movement …, 2018 - Wiley Online Library
ABSTRACT Background: Lilly/Avid's AV‐1451 is one of the most advanced tau PET tracers
in the clinic. Although results obtained in Alzheimer's disease patients are compelling …
in the clinic. Although results obtained in Alzheimer's disease patients are compelling …
[HTML][HTML] Tau positron emission tomography imaging in tauopathies: the added hurdle of off-target binding
Ligands targeting tau for use with positron emission tomography have rapidly been
developed during the past several years, enabling the in vivo study of tau pathology in …
developed during the past several years, enabling the in vivo study of tau pathology in …
International consensus on the use of tau PET imaging agent 18F-flortaucipir in Alzheimer's disease
M Tian, AC Civelek, I Carrio, Y Watanabe… - European journal of …, 2022 - Springer
Purpose Positron emission tomography (PET) with the first and only tau targeting radiotracer
of 18F-flortaucipir approved by FDA has been increasingly used in depicting tau pathology …
of 18F-flortaucipir approved by FDA has been increasingly used in depicting tau pathology …
Neuroimaging in dementia
AM Staffaroni, FM Elahi, D McDermott… - Seminars in …, 2017 - thieme-connect.com
Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging
is playing an increasingly important role. This is in large part due to advances in techniques …
is playing an increasingly important role. This is in large part due to advances in techniques …