Synthesis and pharmacological activities of pyrazole derivatives: A review
Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
The therapeutic voyage of pyrazole and its analogs: a review
Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
Recent advances of pyrazole-containing derivatives as anti-tubercular agents
Z Xu, C Gao, QC Ren, XF Song, LS Feng… - European journal of …, 2017 - Elsevier
One-third of the world's population infected tuberculosis (TB), and more than 1 million
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Unravelling the synthetic and therapeutic aspects of five, six and fused heterocycles using Vilsmeier–Haack reagent
The aim of this review is to encapsulate the synthetic protocols and medicinal aspects of a
wide range of heterocyclic compounds using the Vilsmeier–Haack (VH) reagent. These …
wide range of heterocyclic compounds using the Vilsmeier–Haack (VH) reagent. These …
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Multiple biological activities and molecular docking studies of newly synthesized 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcone hybrids
R Sribalan, G Banuppriya, M Kirubavathi… - Bioorganic & Medicinal …, 2016 - Elsevier
A series of fifteen new chemical entities, 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide
chalcones (6a–o), were synthesized as new hybrids with enriched biological activities …
chalcones (6a–o), were synthesized as new hybrids with enriched biological activities …
Synthesis of azo dyes possessing N-heterocycles and evaluation of their anticancer and antibacterial properties
Abstract A series of 4-(1-azolyl) aniline derivatives (azole= imidazole, benzimidazole,
pyrazole, 3-methylpyrazole, and 4-methylpyrazole) underwent diazotization reaction by …
pyrazole, 3-methylpyrazole, and 4-methylpyrazole) underwent diazotization reaction by …
Therapeutic outlook of pyrazole analogs: A mini review
S Ganguly, S K. Jacob - Mini Reviews in Medicinal Chemistry, 2017 - benthamdirect.com
Background: Pyrazole is one of the excellent structural motifs in medicinal chemistry.
Various physiological and therapeutic possibilities have been exploited by incorporating …
Various physiological and therapeutic possibilities have been exploited by incorporating …
Development and Assessment of 1, 5–Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK–2 as Antiproliferative Agents: A Comprehensive Study through …
New 1, 5-diarylpyrazole oxime hybrid derivatives (scaffolds A and B) were designed,
synthesized, and then their purity was verified using a variety of spectroscopic methods. A …
synthesized, and then their purity was verified using a variety of spectroscopic methods. A …