Hematopoietic stem cell factors: their functional role in self-renewal and clinical aspects
Z Mann, M Sengar, YK Verma, R Rajalingam… - Frontiers in Cell and …, 2022 - frontiersin.org
Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …
differentiation. These properties of HSCs are maintained through hematopoiesis. This …
Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy
M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Bone marrow transplantation therapy relies on the life-long regenerative capacity of
haematopoietic stem cells (HSCs),. HSCs present a complex variety of regenerative …
haematopoietic stem cells (HSCs),. HSCs present a complex variety of regenerative …
Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia
Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
[HTML][HTML] Germline predisposition in myeloid neoplasms: Unique genetic and clinical features of GATA2 deficiency and SAMD9/SAMD9L syndromes
SS Sahoo, EJ Kozyra, MW Wlodarski - Best Practice & Research Clinical …, 2020 - Elsevier
Increasing awareness about germline predisposition and the widespread application of
unbiased whole exome sequencing contributed to the discovery of new clinical entities with …
unbiased whole exome sequencing contributed to the discovery of new clinical entities with …
Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor
outcomes and relapse risk prediction approaches have not changed significantly in …
outcomes and relapse risk prediction approaches have not changed significantly in …
[HTML][HTML] Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia
A Almotiri, H Alzahrani… - The Journal of …, 2021 - Am Soc Clin Investig
JCI - Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid
leukemia Go to JCI Insight About Editors Consulting Editors For authors Publication ethics …
leukemia Go to JCI Insight About Editors Consulting Editors For authors Publication ethics …
Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate
growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks …
growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks …
[HTML][HTML] Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment
JPJ Merlin, H Abrahamse - Biomedicine & Pharmacotherapy, 2024 - Elsevier
CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …
TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
The myeloid transcription factor CEBPA is recurrently biallelically mutated (ie, double
mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic …
mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic …