Early life stress–including experience of child maltreatment, neglect, separation from or loss
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …

Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …

Addiction is a chronic relapsing disorder with devastating personal, societal, and economic
consequences. In humans, early‐life adversity (ELA) such as trauma, neglect, and resource …

Exposure to early life stress (ELS) may lead to long-lasting neurobiological and behavioral
impairments. Alterations in the immune system and neuroinflammatory state induced by ELS …

Failure to appropriately predict and titrate reactivity to threat is a core feature of fear and
anxiety-related disorders and is common following early life adversity (ELA). A population of …

Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated
with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have …

Recent studies have reported that changes in gut microbiota composition could induce
neuropsychiatric problems. In this study, we investigated alterations in gut microbiota …

Repeated maternal separation is the most widely used pre-clinical approach to investigate
the relationship between early-life chronic stress and its neuropsychiatric and physical …

Background Glutamate signaling within the nucleus accumbens underlies motivated
behavior and is involved in psychiatric disease. Although behavioral sex differences in these …

Early life adversity (ELA) increases risk for negative health outcomes, with sex disparities in
prevalence and form of ELA experienced and risk for neuropsychiatric pathology. ELA …