Simple Summary The effect of genetic alteration on the prognosis of patients affected by
GIST has been extensively demonstrated. Unfortunately, not all GISTs could benefit from …

Glioblastoma (GBM) is a fatal brain tumour that is traditionally diagnosed based on
histological features. Recent molecular profiling studies have reshaped the World Health …

摘要近年来, 随着新研究证据的出现, 胃肠间质瘤(GISTs) 领域的国内外指南随之作出更新,
从GISTs 诊断, 生物学行为, 手术治疗到靶向药物治疗, 几乎涵盖了GISTs 管理的每个环节 …

Simple Summary It is not known if surgery, radiation treatment (RT) or other types of
locolregional treatment (LRT) may be beneficial for patients with metastatic gastrointestinal …

Most gastrointestinal stromal tumors (GIST) harbor mutated receptor tyrosine kinase (RTK)
KIT/PDGFRA, which provides an attractive therapeutic target. However, a majority of GISTs …

Simple Summary Among the platelet-derived growth factor receptor (PDGFRA) mutations in
gastrointestinal stromal tumors (GIST), the most frequent is the substitution at position 842 in …

Chromosomal abnormality t (8; 21)(q22; q22) occurs in about 7% of adult patients with de
novo acute myeloid leukemia (AML)[1]. Although t (8; 21) AML is categorized as a favorable …

ABSTRACT Introduction By 1 January 2021, the FDA has approved a total of 62 small-
molecule kinase inhibitors (SMKIs). The increasing clinical use of small-molecule kinase …

Cancer cells can develop resistance to anticancer drugs, thereby becoming tolerant to
treatment through different mechanisms. The biological mechanisms leading to the …

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the
gastrointestinal tract. Surgery and tyrosine kinase inhibitor (TKI) therapy are the main …