Omics approaches for the assessment of biological responses to nanoparticles

Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

Current achievements and applications of transcriptomics in personalized cancer medicine

S Supplitt, P Karpinski, M Sasiadek… - International Journal of …, 2021 - mdpi.com
Over the last decades, transcriptome profiling emerged as one of the most powerful
approaches in oncology, providing prognostic and predictive utility for cancer management …

Niacin-mediated Gene Expression and Role of NiaR as a Transcriptional Repressor of niaX, nadC, and pnuC in Streptococcus pneumoniae

M Afzal, OP Kuipers, S Shafeeq - Frontiers in cellular and infection …, 2017 - frontiersin.org
NAD (Nicotinamide Adenine Dinucleotide) biosynthesis is vital for bacterial physiology and
plays an important role in cellular metabolism. A naturally occurring vitamin B complex …

Advances in human papillomavirus detection for cervical cancer screening and diagnosis: challenges of conventional methods and opportunities for emergent tools

OO Fashedemi, OC Ozoemena, S Peteni… - Analytical …, 2025 - pubs.rsc.org
Human papillomavirus (HPV) infection is the main cause of cervical cancer and other
cancers such as anogenital and oropharyngeal cancers. The prevention screening and …

[PDF][PDF] Exploring the impact of paracetamol on the transcriptome of 價) Streptococcus pneumoniae D39 器響

S Hayat, S Shafeeq, MF Albeshr… - Journal of King Saud …, 2022 - researchgate.net
Objectives: To see how paracetamol affects the transcriptional profile of Streptococcus
pneumonia across the genome. Methods: In this study, microarray analysis was performed …

The Regulation of the AdcR Regulon in Streptococcus pneumoniae Depends Both on Zn2+- and Ni2+-Availability

I Manzoor, S Shafeeq, M Afzal… - Frontiers in Cellular and …, 2015 - frontiersin.org
By using a transcriptomic approach, we have elucidated the effect of Ni2+ on the global
gene expression of S. pneumoniae D39 by identifying several differentially expressed …

Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae

M Afzal, S Shafeeq, I Manzoor, OP Kuipers - PLoS One, 2015 - journals.plos.org
The maltose regulon (mal regulon) has previously been shown to consist of the mal gene
cluster (malMP, malXCD and malAR operons) in Streptococcus pneumoniae. In this study …

Phosphosugar Stress in Bacillus subtilis: Intracellular Accumulation of Mannose 6-Phosphate Derepressed the glcR-phoC Operon from Repression by GlcR

K Morabbi Heravi, I Manzoor, H Watzlawick… - Journal of …, 2019 - Am Soc Microbiol
Bacillus subtilis phosphorylates sugars during or after their transport into the cell.
Perturbation in the conversion of intracellular phosphosugars to the central carbon …

Ni2+-Dependent and PsaR-Mediated Regulation of the Virulence Genes pcpA, psaBCA, and prtA in Streptococcus pneumoniae

I Manzoor, S Shafeeq, OP Kuipers - PLoS One, 2015 - journals.plos.org
Previous studies have shown that the transcriptional regulator PsaR regulates the
expression of the PsaR regulon consisting of genes encoding choline binding protein …

GalR acts as a transcriptional activator of galKT in the presence of galactose in Streptococcus pneumoniae

M Afzal, S Shafeeq, I Manzoor… - Journal of Molecular …, 2016 - karger.com
We explored the regulatory mechanism of Leloir pathway genes in Streptococcus
pneumoniae D39. Here, we demonstrate that the expression of galKT is galactose …