Factor XIII (FXIII) is a multifunctional pro-γ-transglutaminase that, in addition to its well-
known role in hemostasis, has a crucial role in angiogenesis, maintenance of pregnancy …

Factor XIII deficiency (FXIIID) is a rare hereditary bleeding disorder arising from
heterogeneous mutations, which can lead to life‐threatening hemorrhage. The diagnosis of …

The diagnostic and clinical utility of rapid whole genome sequencing (rWGS) for critically ill
children in the intensive care unit (ICU) has been substantiated by multiple studies, but …

ABSTRACT Background: Rare bleeding disorders (RBDs) are heterogeneous disorders,
mostly inherited in an autosomal recessive pattern. Iran is a Mideast country with a high rate …

Factor XIII (FXIII) deficiency is an extremely rare hemorrhagic disorder with an approximate
worldwide incidence of one per two million. With current tests, diagnosis of this disease can …

Intracerebral hemorrhage (ICH) is the most dreaded complication, and the main cause of
death, in patients with congenital bleeding disorders. ICH can occur in all congenital …

Coagulation factor XIII (FXIII) acts as a fine fulcrum in blood plasma that maintains the
balance between bleeding and thrombosis by covalently crosslinking the pre-formed fibrin …

Intracranial hemorrhage (ICH), as a life-threatening bleeding among all kinds of congenital
bleeding disorders (CBDs), is a rare manifestation except in factor XIII (FXIII) deficiency …

Factor XIII (FXIII) deficiency is a rare autosomal recessive disorder that can result in life-
threatening bleeding and early fetal loss. FXIII not only is responsible for cross-linking …

Intracranial hemorrhage (ICH) is a medical emergency. In congenital bleeding disorders,
ICH is a devastating presentation accompanied with a high rate of morbidity and mortality …