Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Nanoceria or cerium oxide nanoparticles characterised by the co-existing of Ce3+ and Ce4+
that allows self-regenerative, redox-responsive dual-catalytic activities, have attracted …

Hybrid insulin peptides (HIPs) form in pancreatic β-cells through the formation of peptide
bonds between proinsulin fragments and other peptides. HIPs have been identified in …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

Simple Summary In this research, we aimed to evaluate the biological effects of physically
gold nanoparticle-collagen nanocarrier incorporated with alkaloid berberine (Au-Col-BB) on …

Biomarkers are molecules that can be used to observe changes in an individual's
biochemical or medical status and provide information to aid diagnosis or treatment …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and affects
millions of individuals globally. AD is associated with cognitive decline and memory loss that …

Colorectal cancer (CRC) is a common and deadly malignancy, ranking second in terms of
mortality and third in terms of incidence on a global scale. The survival rates for CRC …