Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of
the leading known causes of autism. The mutation responsible for FXS is a large expansion …

The discovery that expansion of unstable repeats can cause a variety of neurological
disorders has changed the landscape of disease-oriented research for several forms of …

Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion …

The functions of sleep remain elusive, but a strong link exists between sleep need and
neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a …

Despite the pronounced neurological deficits associated with mental retardation and autism,
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …

How might one determine whether simple animals such as flies sleep in stages? Sleep in
mammals is a dynamic process involving different stages of sleep intensity, and these are …

The mushroom body is required for a variety of behaviors of Drosophila melanogaster.
Different types of intrinsic and extrinsic mushroom body neurons might underlie its functional …

Nascent proteins can be positioned rapidly at precise subcellular locations by local protein
synthesis (LPS) to facilitate localized growth responses. Axon arbor architecture, a major …

Human neurodegenerative diseases are devastating illnesses that predominantly affect
elderly people. The majority of the diseases are associated with pathogenic oligomers from …

Proper brain function requires stringent balance of excitatory and inhibitory synapse
formation during neural circuit assembly. Mutation of genes that normally sculpt and …