Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Gemcitabine, an anticancer agent which acts against a wide range of solid tumors, is known
to be rapidly deaminated in blood to the inactive metabolite 2′, 2′-difluorodeoxyuridine …

Despite rapid advances in cancer diagnosis and treatment, pancreatic cancer remains one
of the most difficult human malignancies to be treated, with a mortality rate nearly equal to its …

The aim of this work was the preparation, characterization, and preliminary evaluation of the
targeting ability toward pancreatic adenocarcinoma cells of liposomes containing the …

In the past, a prodrug design was used as a last option to improve bioavailability through
controlling transport, distribution, metabolism, or other mechanisms. Prodrugs are currently …

Application of nanotechnology in the medical field (ie, nanomedicine) plays an important
role in the development of novel drug delivery methods. Nanoscale drug delivery systems …

The use of X-ray scattering techniques in pharmaceutical science is increasing, in part
through increased collaborations with the materials science community, and through …

The therapeutic efficacy of gemcitabine is severely compromised due to its rapid plasma
metabolism. Moreover, its hydrophilicity poses a challenge for its efficient entrapment in …

Hepatoma is one of the most severe malignancies usually with poor prognosis, and many
patients are insensitive to the existing therapeutic agents, including the drugs for …

Solid lipid nanoparticles (SLNs) comprise a versatile drug delivery system that has been
developed for the treatment of a variety of diseases. The present study will investigate the …