Apoptosis and its therapeutic implications in neurodegenerative diseases

NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

Potential of therapeutic small molecules in apoptosis regulation in the treatment of neurodegenerative diseases: An updated review

HG Dailah - Molecules, 2022 - mdpi.com
Neurodegenerative disorders (NDs) include Parkinson's disease (PD), Alzheimer's disease
(AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the common …

Deep Learning for Microfluidic-Assisted Caenorhabditis elegans Multi-Parameter Identification Using YOLOv7

J Zhang, S Liu, H Yuan, R Yong, S Duan, Y Li… - Micromachines, 2023 - mdpi.com
The Caenorhabditis elegans (C. elegans) is an ideal model organism for studying human
diseases and genetics due to its transparency and suitability for optical imaging. However …

Microfluidic-Assisted Caenorhabditis elegans Sorting: Current Status and Future Prospects

H Yuan, W Yuan, S Duan, K Jiao, Q Zhang… - Cyborg and Bionic …, 2023 - spj.science.org
Caenorhabditis elegans (C. elegans) has been a popular model organism for several
decades since its first discovery of the huge research potential for modeling human diseases …

Quantifying levels of dopaminergic neuron morphological alteration and degeneration in Caenorhabditis elegans

SR Bijwadia, K Morton… - Journal of visualized …, 2021 - pmc.ncbi.nlm.nih.gov
Dopamine neuron loss is involved in the pathology of Parkinson's Disease (PD), a highly
prevalent neurodegenerative disorder affecting over 10 million people worldwide. Since …

Fly-on-a-Chip: Microfluidics for Drosophila melanogaster Studies

A Zabihihesari, AJ Hilliker, P Rezai - Integrative Biology, 2019 - academic.oup.com
The fruit fly or Drosophila melanogaster has been used as a promising model organism in
genetics, developmental and behavioral studies as well as in the fields of neuroscience …

Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation

R Li, X Huang, L Shen, T Zhang, N Liu, X Hou… - Cellular and Molecular …, 2024 - Springer
Lewy body diseases (LBD) comprise a group of complex neurodegenerative conditions
originating from accumulation of misfolded alpha-synuclein (α-syn) in the form of Lewy …

Parkinson's disease and the gut: Models of an emerging relationship

AJ Bindas, S Kulkarni, RA Koppes, AN Koppes - Acta biomaterialia, 2021 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disease characterized by a
progressive loss of fine motor function that impacts 1-2 out of 1,000 people. PD occurs …

A perspective of active microfluidic platforms as an enabling tool for applications in other fields

M Hébert, J Huissoon, CL Ren - Journal of Micromechanics and …, 2022 - iopscience.iop.org
Microfluidics has progressed tremendously as a field over the last two decades. Various
areas of microfluidics developed in fully-fledged domains of their own such as organ-on-a …

Microfluidic electric parallel egg-laying assay and application to in-vivo toxicity screening of microplastics using C. elegans

K Youssef, D Archonta, TJ Kubiseski, A Tandon… - Science of The Total …, 2021 - Elsevier
Environmental pollutants like microplastics are posing health concerns on aquatic animals
and the ecosystem. Microplastic toxicity studies using Caenorhabditis elegans (C. elegans) …