[HTML][HTML] Tissue resident memory T cells in the respiratory tract

MZM Zheng, LM Wakim - Mucosal immunology, 2022 - Elsevier
Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …

Immune surveillance of cytomegalovirus in tissues

A Mihalić, J Železnjak, B Lisnić, S Jonjić… - Cellular & molecular …, 2024 - nature.com
Cytomegalovirus (CMV), a representative member of the Betaherpesvirinae subfamily of
herpesviruses, is common in the human population, but immunocompetent individuals are …

Opportunities and challenges for T cell-based influenza vaccines

TR Mosmann, AJ McMichael, A LeVert… - Nature Reviews …, 2024 - nature.com
Vaccination remains our main defence against influenza, which causes substantial annual
mortality and poses a serious pandemic threat. Influenza virus evades immunity by rapidly …

Anti-viral protective capacity of tissue resident memory T cells

DH Paik, DL Farber - Current opinion in virology, 2021 - Elsevier
It has become increasingly clear that a subset of T cells which persist at diverse infection
sites, known as tissue-resident memory T cells (T RM), can mediate efficacious protective …

The roles of tissue-resident memory T cells in lung diseases

R Yuan, J Yu, Z Jiao, J Li, F Wu, R Yan… - Frontiers in …, 2021 - frontiersin.org
The unique environment of the lungs is protected by complex immune interactions. Human
lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen …

ChAdOx1‐S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination

M Cokarić Brdovčak, J Materljan… - European journal of …, 2022 - Wiley Online Library
COVID‐19 vaccines prevent severe forms of the disease, but do not warrant complete
protection against breakthrough infections. This could be due to suboptimal mucosal …

Cytomegalovirus vaccine vector-induced effector memory CD4+ T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

D Malouli, M Tiwary, RM Gilbride, DW Morrow… - Nature …, 2024 - nature.com
An influenza vaccine approach that overcomes the problem of viral sequence diversity and
provides long-lived heterosubtypic protection is urgently needed to protect against …

Systemic and mucosal B and T cell responses upon mucosal vaccination of teleost fish

E Muñoz-Atienza, P Díaz-Rosales… - Frontiers in …, 2021 - frontiersin.org
The development of mucosal vaccines against pathogens is currently a highly explored area
of research in both humans and animals. This is due to the fact that mucosal vaccines have …

T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines

M Li, C Chen, X Wang, P Guo, H Feng, X Zhang… - Antiviral Research, 2023 - Elsevier
Vaccines that trigger mucosal immune responses at the entry portals of pathogens are
highly desired. Here, we showed that antigen-decorated nanoparticle generated through …

Mucosal T-cell responses to chronic viral infections: Implications for vaccine design

M Al-Talib, S Dimonte, IR Humphreys - Cellular & Molecular …, 2024 - nature.com
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the
major interfaces between the immune system and the environment. Their unique …