Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …

The extracellular matrix plays a key role in synapse formation and in the modulation of
synaptic function in the central nervous system. Recent investigations have revealed that …

Much remains unknown about the etiology of compulsion-like alcohol drinking, where
consumption persists despite adverse consequences. The role of the anterior insula (AIC) in …

Compulsive drug intake is characterized by the continuation of use regardless of negative
consequences. This is modeled preclinically using procedures where a negative stimulus is …

Introduction Alcohol consumption despite negative consequences is a core symptom of
alcohol use disorder. This can be modeled in mice by pairing aversive stimuli with alcohol …

Abstract Substance Use Disorders (SUDs) manifest as persistent drug-seeking behavior
despite adverse consequences, with Alcohol Use Disorder (AUD) and Opioid Use Disorder …

Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix
enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that …

Aims Continued alcohol consumption despite negative consequences is a core symptom of
alcohol use disorder. This is modeled in mice by pairing negative stimuli with alcohol, such …

Blunted sensitivity to ethanol's aversive effects can increase motivation to consume ethanol;
yet, the neurobiological circuits responsible for encoding these aversive properties are not …