A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

The architectures of iterative type I PKS and FAS

DA Herbst, CA Townsend, T Maier - Natural product reports, 2018 - pubs.rsc.org
Covering: up to mid of 2018 Type I fatty acid synthases (FASs) are giant multienzymes
catalyzing all steps of the biosynthesis of fatty acids from acetyl-and malonyl-CoA by iterative …

Protein denaturation at the air-water interface and how to prevent it

E D'Imprima, D Floris, M Joppe, R Sánchez… - Elife, 2019 - elifesciences.org
Electron cryo-microscopy analyzes the structure of proteins and protein complexes in
vitrified solution. Proteins tend to adsorb to the air-water interface in unsupported films of …

[HTML][HTML] Recent advances in microbial production of medium chain fatty acid from renewable carbon resources: A comprehensive review

JH Ahn, KH Jung, ES Lim, SM Kim, SO Han… - Bioresource technology, 2023 - Elsevier
Microbial production of medium chain length fatty acids (MCFAs) from renewable resources
is becoming increasingly important in establishing a sustainable and clean chemical …

Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids

Z Zhu, Y Hu, PG Teixeira, R Pereira, Y Chen… - Nature Catalysis, 2020 - nature.com
Medium-chain fatty acids (MCFAs; C6–C12) are valuable molecules used for biofuel and
oleochemical production; however, it is challenging to synthesize these fatty acids efficiently …

Recent trends in metabolic engineering of microbial chemical factories

Y Liu, J Nielsen - Current opinion in biotechnology, 2019 - Elsevier
Highlights•Microbial cell factories can be tailored for producing certain 'drop-in'chemicals.•
Metabolic engineering has greatly enhanced the development of microbial cell …

Development of an efficient yeast platform for cannabigerolic acid biosynthesis

Y Zhang, J Guo, PZ Gao, W Yan, J Shen, X Luo… - Metabolic …, 2023 - Elsevier
Cannabinoids are important therapeutical molecules for human ailments, cancer treatment,
and SARS-CoV-2. The central cannabinoid, cannabigerolic acid (CBGA), is generated from …

Microbial synthesis of medium-chain chemicals from renewables

S Sarria, NS Kruyer, P Peralta-Yahya - Nature Biotechnology, 2017 - nature.com
Abstract Linear, medium-chain (C8–C12) hydrocarbons are important components of fuels
as well as commodity and specialty chemicals. As industrial microbes do not contain …

[HTML][HTML] Engineering microbial fatty acid metabolism for biofuels and biochemicals

ER Marella, C Holkenbrink, V Siewers… - Current opinion in …, 2018 - Elsevier
Highlights•In the future, oleochemicals can be produced by microbes from biomass
feedstocks.•Microbial fatty-acid metabolism is engineered to produce diverse …

Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae

T Gülck, JK Booth, Â Carvalho… - Journal of Natural …, 2020 - ACS Publications
Phytocannabinoids are a group of plant-derived metabolites that display a wide range of
psychoactive as well as health-promoting effects. The production of pharmaceutically …