Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology

Z Huang, PF Lai, ATH Cocker… - Biochemical Society …, 2023 - portlandpress.com
Protein N-linked glycosylation is a structurally diverse post-translational modification that
stores biological information in a larger order of magnitude than other post-translational …

Murine trophoblast organoids as a model for trophoblast development and CRISPR-Cas9 screening

Q Mao, Q Ye, Y Xu, J Jiang, Y Fan, L Zhuang, G Liu… - Developmental Cell, 2023 - cell.com
The placenta becomes one of the most diversified organs during placental mammal
radiation. The main in vitro model for studying mouse trophoblast development is the 2D …

Deciphering the divergent transcriptomic landscapes of cervical cancer cells grown in 3D and 2D cell culture systems

R Kumar, M Iden, SW Tsaih, R Schmidt… - Frontiers in Cell and …, 2024 - frontiersin.org
Cervical cancer remains a significant health challenge for women worldwide, with a
disproportionate impact on developing regions like sub-Saharan Africa. Taking advantage of …

The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis

M Zhang, Y Jing, W Xu, X Shi, W Zhang, P Chen… - Cell Death & …, 2023 - nature.com
Hepatic stellate cell is one of the major nonparenchymal cell types in liver. It has been
proved the hepatic stellate cells are activated upon liver injury and produce excessive …

[HTML][HTML] Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism

HW Yung, X Zhao, L Glover, C Burrin, PC Pang… - Iscience, 2023 - cell.com
Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We
hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE) …

Evolution of placental hormones: implications for animal models

AM Carter - Frontiers in endocrinology, 2022 - frontiersin.org
Human placenta secretes a variety of hormones, some of them in large amounts. Their
effects on maternal physiology, including the immune system, are poorly understood. Not …

High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester

TL Gonzalez, S Wertheimer, AE Flowers… - Biology of …, 2024 - academic.oup.com
The placenta, composed of chorionic villi, changes dramatically across gestation.
Understanding differences in ongoing pregnancies are essential to identify the role of …

Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy

LA Beer, X Yin, J Ding, S Senapati, MD Sammel… - Clinical Proteomics, 2023 - Springer
Background Differentiating between a normal intrauterine pregnancy (IUP) and abnormal
conditions including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical …

A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface

F Zhao, AC Tallarek, Y Wang, Y Xie, A Diemert… - Frontiers in …, 2023 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a
risk of infection and disease in pregnant women and neonates. Successful pregnancy …

Low pregnancy-specific beta-1-glycoprotein is associated with nondipper hypertension and increased risk of preeclampsia in pregnant women with newly diagnosed …

K Toprak, Z Yıldız, S Akdemir, K Esen… - … Journal of Clinical …, 2023 - Taylor & Francis
Chronic hypertension is one of the major risk factors for preeclampsia. Pregnancy-specific
beta-1-glycoprotein (PSG-1) is a protein that plays a critical role in fetomaternal immune …