Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Inflammation has been identified as one of the main pathophysiological mechanisms
underlying neuropsychiatric and neurodegenerative disorders. Despite the role of …

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can exert antidepressant,
anti-inflammatory and neuroprotective properties, but the exact molecular mechanism …

Background Major depressive disorder (MDD) is highly debilitating, difficult to treat, has a
high rate of recurrence, and negatively impacts the individual and society as a whole. One …

Background & Objective: A number of neuropsychiatric disorders, including Parkinson's
disease, schizophrenia, attention deficit hyperactivity disorder, and, to some extent …

Adult hippocampal neurogenesis generates functional neurons from neural progenitor cells
in the hippocampal dentate gyrus (DG) to complement and repair neurons and neural …

The prevalence of neurologic and psychiatric diseases has been increasing for decades
and, given the moderate therapeutic efficacy and safety profile of existing pharmacological …

Glucocorticoids have been suggested to be involved in several neuropsychiatric disorders,
including depression. One of the possible mechanisms through which glucocorticoids …

Major depressive disorders (MDDs) are often associated with a deficiency in long-chain
omega-3 polyunsaturated fatty acids (ω-3 PUFAs), as well as signs of low-grade …

Since depression remains a major public health issue there is a constant need for new and
more efficient therapeutic strategies based on the mechanisms involved in the aetiology of …