Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Inverse protein folding is challenging due to its inherent one-to-many mapping
characteristic, where numerous possible amino acid sequences can fold into a single …

Over the past decade, short-read sequence alignment has become a mature technology.
Optimized algorithms, careful software engineering and high-speed hardware have …

Fungal infections have become a significant global health issue, affecting millions
worldwide. Antifungal peptides (AFPs) have emerged as a promising alternative to …

Abstract Many theories in Public Administration and Public Management explicitly relate to
changes over time in the attitudes, values, perceptions, and/or motivations of public‐sector …

Low complexity regions are fragments of protein sequences composed of only a few types of
amino acids. These regions frequently occur in proteins and can play an important role in …

Drug discovery has become a main challenge in the society, following the COVID‐19
pandemic. However, pharmaceutical companies are already using computing to accelerate …

Purpose Conditions and thresholds applied for evidence weighting of within-codon
concordance (PM5) for pathogenicity vary widely between laboratories and expert groups …

In this paper, we propose a data embedding technique for structured data that allows for the
direct application of standard vector-based machine learning models without the need for …

The relative contribution of mutation and selection to the amino acid substitution rates
observed in empirical matrices is unclear. Herein, we present a neutral continuous fitness …