Role of transcription factors, noncoding RNAs, epitranscriptomics, and epigenetics in post‐ischemic neuroinflammation

SL Mehta, V Arruri, R Vemuganti - Journal of Neurochemistry, 2024 - Wiley Online Library
Post‐stroke neuroinflammation is pivotal in brain repair, yet persistent inflammation can
aggravate ischemic brain damage and hamper recovery. Following stroke, specific …

CDR1as regulates α-synuclein-mediated ischemic brain damage by controlling miR-7 availability

SL Mehta, AK Chokkalla, S Bathula, V Arruri… - … Therapy-Nucleic Acids, 2023 - cell.com
Transient focal ischemia decreased microRNA-7 (miR-7) levels, leading to derepression of
its major target α-synuclein (α-Syn) that promotes secondary brain damage. Circular RNA …

Tau and GSK-3β are critical contributors to α-synuclein-mediated post-stroke brain damage

SL Mehta, TH Kim, B Chelluboina… - Neuromolecular …, 2023 - Springer
Post-stroke secondary brain damage is significantly influenced by the induction and
accumulation of α-Synuclein (α-Syn). α-Syn-positive inclusions are often present in …

Post-stroke brain can be protected by modulating the lncRNA FosDT

SL Mehta, B Chelluboina… - Journal of Cerebral …, 2024 - journals.sagepub.com
We previously showed that knockdown or deletion of Fos downstream transcript (FosDT; a
stroke-induced brain-specific long noncoding RNA) is neuroprotective. We presently tested …

The Roles of Non-coding RNA Targeting Astrocytes in Cerebral Ischemia

C Long, Z Li, W Song, X Zeng, R Yang, L Lu - Molecular Neurobiology, 2024 - Springer
Astrocytes are key targets for treating cerebral ischemia in the central nervous system. Non-
coding RNAs (ncRNAs) participate in the pathological processes of astrocytes in cerebral …

Therapeutic Potential of Intravenous miR-21 Mimic after Stroke Following STAIR Criteria

B Chelluboina, S Jeong, CK Davis, SL Mehta… - Translational Stroke …, 2023 - Springer
Abstract The microRNA-21 (miR-21) levels in the brain are crucial in determining post-stroke
brain damage and recovery. The miR-21 exerts neuroprotection by targeting mRNAs that …

Stroke triggers dynamic m6A reprogramming of cerebral circular RNAs

SL Mehta, H Namous, R Vemuganti - Neurochemistry International, 2024 - Elsevier
We previously showed that stroke alters circular RNA (circRNA) expression profiles. Many
circRNAs undergo epitranscriptomic modifications, particularly methylation of adenosine to …

Floralozone regulates MiR-7a-5p expression through AMPKα2 activation to improve cognitive dysfunction in vascular dementia

YT Song, SS Li, CY Chao, GZ Chen, SX Wang… - Experimental …, 2024 - Elsevier
Background The pathogenesis of vascular dementia (VD) is complex, and currently, no
effective treatments have been recommended. Floralozone is a colorless liquid first …

Combined Analysis of Human and Experimental Rat Samples Identified Biomarkers for Ischemic Stroke

Q Chen, X Li, Y Yang, J Ni, J Chen - Molecular Neurobiology, 2024 - Springer
The genetic transcription profile and underlying molecular mechanisms of ischemic stroke
(IS) remain elusive. To address this issue, four mRNA and one miRNA expression profile of …

Are Ischemic Stroke and Alzheimer's Disease Genetically Consecutive Pathologies?

IB Filippenkov, AV Khrunin, IV Mozgovoy… - Biomedicines, 2023 - mdpi.com
Complex diseases that affect the functioning of the central nervous system pose a major
problem for modern society. Among these, ischemic stroke (IS) holds a special place as one …