Recent advances in contrast-enhanced photoacoustic imaging: overcoming the physical and practical challenges
For decades now, photoacoustic imaging (PAI) has been investigated to realize its potential
as a niche biomedical imaging modality. Despite its highly desirable optical contrast and …
as a niche biomedical imaging modality. Despite its highly desirable optical contrast and …
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - Elsevier
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
X Hu, C Gattis, AG Olroyd, AM Friera, K White… - Science translational …, 2023 - science.org
Transplantation of allogeneic pancreatic donor islets has successfully been performed in
selected patients with difficult-to-control insulin-dependent diabetes and impaired …
selected patients with difficult-to-control insulin-dependent diabetes and impaired …
Advances in β-cell replacement therapy for the treatment of type 1 diabetes
The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to
reduce disease complications. For some patients, technological approaches to insulin …
reduce disease complications. For some patients, technological approaches to insulin …
β-cell mass and turnover in humans: effects of obesity and aging
OBJECTIVE We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in
humans in response to obesity and advanced age. RESEARCH DESIGN AND METHODS …
humans in response to obesity and advanced age. RESEARCH DESIGN AND METHODS …
[HTML][HTML] Radiolabeled peptides: valuable tools for the detection and treatment of cancer
M Fani, HR Maecke, SM Okarvi - Theranostics, 2012 - ncbi.nlm.nih.gov
Human cancer cells overexpress many peptide receptors as molecular targets.
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …
Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications
B Manandhar, JM Ahn - Journal of medicinal chemistry, 2015 - ACS Publications
Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in
glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin …
glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin …
Radiopharmaceutical development of radiolabelled peptides
M Fani, HR Maecke - European journal of nuclear medicine and …, 2012 - Springer
Receptor targeting with radiolabelled peptides has become very important in nuclear
medicine and oncology in the past few years. The overexpression of many peptide receptors …
medicine and oncology in the past few years. The overexpression of many peptide receptors …
[HTML][HTML] Type 1 diabetes and engineering enhanced islet transplantation
The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
Peptide receptor radionuclide therapy: an overview
Peptide receptor radionuclide therapy (PRRT) is a site-directed targeted therapeutic strategy
that specifically uses radiolabeled peptides as biological targeting vectors designed to …
that specifically uses radiolabeled peptides as biological targeting vectors designed to …