Age-related macular degeneration

EK de Jong, MJ Geerlings, AI den Hollander - Genetics and genomics of …, 2020 - Elsevier
Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been …

Predictors of visual acuity after treatment of neovascular age-related macular degeneration–current perspectives

LT Phan, GK Broadhead, TH Hong… - Clinical …, 2021 - Taylor & Francis
Visual acuity is a key outcome measure in the treatment of neovascular age-related macular
degeneration (nAMD) using anti-vascular endothelial growth factor agents. Large variations …

Genetic variants affecting anti-VEGF drug response in polypoidal choroidal vasculopathy patients: a systematic review and meta-analysis

X Díaz-Villamarín, D Blánquez-Martínez… - Genes, 2020 - mdpi.com
Polypoidal choroidal vasculopathy (PCV) is usually regarded as a subtype of choroidal
neovascularization (CNV) that is secondary to age-related macular degeneration (AMD) …

Exploring the use of molecular biomarkers for precision medicine in age-related macular degeneration

L Lorés-Motta, EK de Jong, AI den Hollander - Molecular diagnosis & …, 2018 - Springer
Precision medicine aims to improve patient care by adjusting medication to each patient's
individual needs. Age-related macular degeneration (AMD) is a heterogeneous eye disease …

Predictive genetics for AMD: Hype and hopes for genetics-based strategies for treatment and prevention

MB Gorin - Experimental eye research, 2020 - Elsevier
Age-related macular degeneration (AMD) is a complex disease with multiple genetic and
environmental risk factors. In the age of molecular genetics, many investigators have …

ABCA1 rs1883025 and CYP4F2 rs2108622 Gene Polymorphism Association with Age-Related Macular Degeneration and Anti-VEGF Treatment

R Mockute, A Vilkeviciute, VJ Balciuniene… - Medicina, 2021 - mdpi.com
Background and Objectives: The age-related macular degeneration (AMD) pathophysiology
is multifactorial, as it consists of interactions between aging, genetic, and environmental …

Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration

F He, X Li, S Cai, L Lu, T Zhang, M Yang, N Fan… - Eye, 2022 - nature.com
Objectives To investigate the role of polymorphism rs11200638 of high-temperature
requirement factor A-1 (HtrA1) gene in the pathogenesis of age-related macular …

Gene polymorphisms associated with an increased risk of exudative age-related macular degeneration in a Spanish population

P Gili, L Lloreda Martín… - European Journal …, 2022 - journals.sagepub.com
Purpose: To identify the association between single-nucleotide polymorphisms (SNPs) in
CFH, ARMS2, HTRA1, CFB, C2, and C3 genes and exudative age-related macular …

Meta-Analysis of the Pharmacogenetics of ARMS2 A69S Polymorphism and the Response to Advanced Age-Related Macular Degeneration

J Zhang, Z Liu, S Hu, J Qi - Ophthalmic research, 2021 - karger.com
Age-related macular degeneration (AMD) causes irreversible vision loss, and targeted anti-
vascular endothelial growth factor (VEGF) therapy is now the most common and effective …

Association of the HtrA1 rs11200638 Polymorphism with Neovascular Age-Related Macular Degeneration in Indonesia

S Supanji, ABI Perdamaian, DF Romdhoniyyah… - Ophthalmology and …, 2022 - Springer
Introduction The aim of this study was to investigate the association of the HtrA1 rs11200638
polymorphism with neovascular age-related macular degeneration (nAMD) in Indonesia …