The challenges in making animal models of complex human epilepsy phenotypes with
varied aetiology highlights the need to develop alternative disease models that can address …

The blood–brain barrier (BBB) is a physiological barrier maintaining a specialized brain
micromilieu that is necessary for proper neuronal function. Endothelial tight junctions and …

Human pluripotent stem cell (hPSC)-derived neurons provide exciting opportunities for in
vitro modeling of neurological diseases and for advancing drug development and …

The maturation and functional characteristics of human induced pluripotent stem cell
(hiPSC)-cortical neurons has not been fully documented. This study developed a phenotypic …

Epilepsies are a group of neurological disorders characterised by recurrent epileptic
seizures. Seizures, defined as abnormal transient discharges of neuronal activity, can affect …

Seizures are life-threatening adverse drug reactions which are investigated late in drug
development using rodent models. Consequently, if seizures are detected, a lot of time …

Astrocytes and neurons respond to each other by releasing transmitters, such as γ-
aminobutyric acid (GABA) and glutamate, that modulate the synaptic transmission and …

The electrophysiological technology having a high spatiotemporal resolution at the single‐
cell level and noninvasive measurements of large areas provide insights on underlying …

A sizeable proportion of drug attrition is due to drug-induced seizures. Currently available
animal models frequently fail to predict human seizure liability. Therefore, there is a need for …

Background Microelectrode array (MEA) systems are valuable for in vitro assessment of
neurotoxicity and drug efficiency. However, several difficulties such as protracted functional …