[HTML][HTML] Frailty and sarcopenia: the potential role of an aged immune system

D Wilson, T Jackson, E Sapey, JM Lord - Ageing research reviews, 2017 - Elsevier
Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …

The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

BK Kennedy, DW Lamming - Cell metabolism, 2016 - cell.com
Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

Age-related changes in skeletal muscle: changes to life-style as a therapy

R McCormick, A Vasilaki - Biogerontology, 2018 - Springer
As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

The role of the IGF-1 signaling cascade in muscle protein synthesis and anabolic resistance in aging skeletal muscle

RD Barclay, NA Burd, C Tyler, NA Tillin… - Frontiers in …, 2019 - frontiersin.org
Sarcopenia is defined as the combined loss of skeletal muscle strength, function, and/or
mass with aging. This degenerative loss of muscle mass is associated with poor quality of …

Sarcopenia in menopausal women: current perspectives

F Buckinx, M Aubertin-Leheudre - International Journal of Women's …, 2022 - Taylor & Francis
Menopause is associated with hormonal changes, which could accelerate or lead to
sarcopenia. Functional impairment and physical disability are the major consequences of …

Nutrition in menopausal women: a narrative review

TR Silva, K Oppermann, FM Reis, PM Spritzer - Nutrients, 2021 - mdpi.com
Among the various aspects of health promotion and lifestyle adaptation to the
postmenopausal period, nutritional habits are essential because they concern all women …

Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies

GB Kubat, E Bouhamida, O Ulger, I Turkel, G Pedriali… - Mitochondrion, 2023 - Elsevier
Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

The mixed blessing of AMPK signaling in Cancer treatments

M Sadria, D Seo, AT Layton - BMC cancer, 2022 - Springer
Background Nutrient acquisition and metabolism pathways are altered in cancer cells to
meet bioenergetic and biosynthetic demands. A major regulator of cellular metabolism and …

Lifelong aerobic exercise alleviates sarcopenia by activating autophagy and inhibiting protein degradation via the AMPK/PGC-1α signaling pathway

J Liang, H Zhang, Z Zeng, L Wu, Y Zhang, Y Guo, J Lv… - Metabolites, 2021 - mdpi.com
Sarcopenia is an aging-induced syndrome characterized by a progressive reduction of
skeletal muscle mass and strength. Increasing evidence has attested that appropriate and …

Effects of protein supplementation combined with exercise intervention on frailty indices, body composition, and physical function in frail older adults

CD Liao, PH Lee, DJ Hsiao, SW Huang, JY Tsauo… - Nutrients, 2018 - mdpi.com
Aging poses a high risk of lean mass loss, which can be effectively improved through
resistance exercise training (RET), or multicomponent exercise training (MET) as well as …