The art of finding the right drug target: emerging methods and strategies

ZC Jia, X Yang, YK Wu, M Li, D Das, MX Chen… - Pharmacological …, 2024 - Elsevier
Drug targets are specific molecules in biological tissues and body fluids that interact with
drugs. Drug target discovery is a key component of drug discovery and is essential for the …

Progress and Perspective of CRISPR‐Cas9 Technology in Translational Medicine

R Zheng, L Zhang, R Parvin, L Su, J Chi… - Advanced …, 2023 - Wiley Online Library
Translational medicine aims to improve human health by exploring potential treatment
methods developed during basic scientific research and applying them to the treatment of …

Functional genomics using CRISPR-Cas systems, compositions, methods, screens and applications thereof

F Zhang, O Shalem, NE Sanjana, J Doench… - US Patent …, 2020 - Google Patents
The present invention generally relates to libraries, compositions, methods, applications, kits
and screens used in functional genomics that focus on gene function in a cell and that may …

Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components

F Zhang, L Cong, RAN Fei, M Heidenreich… - US Patent …, 2021 - Google Patents
2020-05-07 First worldwide family litigation filed litigation Critical https://patents. darts-ip.
com/? family= 52105124&utm_source= google_patent&utm_medium …

Genome centric engineering using ZFNs, TALENs and CRISPR-Cas9 systems for trait improvement and disease control in Animals

AK Wani, N Akhtar, R Singh, A Prakash… - Veterinary research …, 2023 - Springer
Livestock is an essential life commodity in modern agriculture involving breeding and
maintenance. The farming practices have evolved mainly over the last century for …

Recent progress in CRISPR/Cas9-based genome editing for enhancing plant disease resistance

H Boubakri - Gene, 2023 - Elsevier
Nowadays, agricultural production is strongly affected by both climate change and pathogen
attacks which seriously threaten global food security. For a long time, researchers have …

Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation

F Zhang, C Lin, RAN Fei - US Patent 11,008,588, 2021 - Google Patents
2016-06-20 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders

B Davidson, C Lin, E Rodriguez, F Zhang - US Patent 10,851,357, 2020 - Google Patents
The invention provides for delivery, engineering and optimization of systems, methods, and
compositions for manipulation of sequences and/or activities of target sequences especially …

A history of genome editing in mammals

A Fernández, S Josa, L Montoliu - Mammalian Genome, 2017 - Springer
Genome editing is now a routine procedure in many mammalian genetics laboratories. The
ostensibly short but intense history of genome-editing approaches illustrates how a …

Delivery and use of the CRISPR-CAS systems, vectors and compositions for hepatic targeting and therapy

F Zhang, L Cong, RAN Fei - US Patent 12,018,275, 2024 - Google Patents
2024-03-04 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE
BROAD INSTITUTE, INC. reassignment PRESIDENT AND FELLOWS OF HARVARD …