Immunomodulatory drugs in multiple myeloma: mechanisms of action and clinical experience

SA Holstein, PL McCarthy - Drugs, 2017 - Springer
Over the last two decades, the outcomes for patients with multiple myeloma, a plasma cell
malignancy, have dramatically improved. The development of the immunomodulatory drugs …

Prevention of thalidomide-and lenalidomide-associated thrombosis in myeloma

A Palumbo, SV Rajkumar, MA Dimopoulos… - Leukemia, 2008 - nature.com
The incidence of venous thromboembolism (VTE) is more than 1‰ annually in the general
population and increases further in cancer patients. The risk of VTE is higher in multiple …

Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma …

A Palumbo, S Bringhen, T Caravita, E Merla… - The Lancet, 2006 - thelancet.com
Background Since 1960, oral melphalan and prednisone (MP) has been regarded as the
standard of care in elderly multiple myeloma patients. This multicentre randomised trial …

Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma

Y Liu, J Zhou, Q Li, L Li, Y Jia, F Geng, J Zhou… - Advanced Drug Delivery …, 2021 - Elsevier
Remarkable advances in nano delivery systems have provided new hope for tumor
prevention, diagnosis and treatment. However, only limited clinical therapeutic effects …

Thalidomide for treatment of multiple myeloma: 10 years later

A Palumbo, T Facon, P Sonneveld… - Blood, The Journal …, 2008 - ashpublications.org
Thalidomide, bortezomib, and lenalidomide have recently changed the treatment paradigm
of myeloma. In young, newly diagnosed patients, the combination of thalidomide and …

Venous thromboembolism in the hematologic malignancies

A Falanga, M Marchetti - Journal of Clinical Oncology, 2009 - ascopubs.org
Patients with hematologic malignancies are at high risk of thrombotic or hemorrhagic
complications. The incidence of these events is greatly variable and is influenced by many …

A systematic review of phase‐II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma

A Glasmacher, C Hahn, F Hoffmann… - British journal of …, 2006 - Wiley Online Library
The activity of thalidomide in relapsed or refractory multiple myeloma is widely accepted but
not yet demonstrated in a randomised‐controlled trial. A systematic review of the published …

[HTML][HTML] Rates of venous thromboembolism in multiple myeloma patients undergoing immunomodulatory therapy with thalidomide or lenalidomide: a systematic …

M Carrier, G Le Gal, J Tay, C Wu, AY Lee - Journal of Thrombosis and …, 2011 - Elsevier
Introduction: The incidence of venous thromboembolism (VTE) in patients with multiple
myeloma (MM) treated with thalidomide‐and lenalidomide‐based regimens is high. Recent …

Nanodrug delivery systems: a promising technology for detection, diagnosis, and treatment of cancer

A Babu, AK Templeton, A Munshi, R Ramesh - Aaps Pharmscitech, 2014 - Springer
Nanotechnology has enabled the development of novel therapeutic and diagnostic
strategies, such as advances in targeted drug delivery systems, versatile molecular imaging …

Treatment of newly diagnosed multiple myeloma based on Mayo Stratification of Myeloma and Risk-adapted Therapy (mSMART): consensus statement

A Dispenzieri, SV Rajkumar, MA Gertz, MQ Lacy… - Mayo Clinic …, 2007 - Elsevier
Multiple myeloma is a neoplastic plasma cell dyscrasia that on a yearly basis affects nearly
17,000 individuals and kills more than 11,000. Although no cure exists, many effective …