Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

Purpose The complement pathway may play a key role in the pathogenesis of age-related
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …

The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer
disease; however, their interrelatedness remains poorly understood. The complement …

Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Abstract Background Hydrogen peroxide (H 2 O 2)-induced mitochondrial oxidative damage
is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H 2 O 2 …

The complement activation product C3a is often described as a proinflammatory mediator,
alongside its downstream cousin, C5a. However, emerging studies show that C3a has …