Development and Therapeutic Perspectives of CXCR4 Antagonists for Disease Therapy

J Yang, E Tian, L Chen, Z Liu, Y Ren, W Mao… - European Journal of …, 2024 - Elsevier
Abstract Chemokine receptor 4 (CXCR4) is a subtype receptor protein of the GPCR family
with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is …

Exploring characteristics of placental transcriptome and cord serum metabolome associated with low birth weight in Kele pigs

C Zhang, Z Wu, G Hu, Y Zhang, Z Ao - Tropical Animal Health and …, 2023 - Springer
The neonate with low birth weight (LBW) resulted from intrauterine growth retardation
(IUGR) exists a substantial risk of postpartum death. Placental insufficiency is responsible for …

Myometrial‐derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in mice

L Zhang, R Mamillapalli, S Habata… - Journal of Cellular …, 2022 - Wiley Online Library
Preterm birth is a major contributor to neonatal mortality and morbidity. Infection results in
elevation of inflammation‐related cytokines followed by infiltration of immune cells into …

Inhibition of the CXC motif chemokine 12 (CXCL12) and its receptor CXCR4 reduces utero-placental expression of the VEGF system and increases utero-placental …

RL Ashley, CL Runyan, MM Maestas… - Frontiers in Veterinary …, 2021 - frontiersin.org
The placenta, a unique organ that only develops during pregnancy, is essential for nutrient,
oxygen, and waste exchange between offspring and mother. Yet, despite its importance, the …

Role of chemokines in early pregnancy loss

S Gokce, D Herkiloglu, O Cevik… - Experimental and …, 2022 - spandidos-publications.com
The present study aimed to compare decidual protein levels and gene expression levels of
chemokines between patients with early pregnancy loss and those with voluntary abortion. A …

Placental insufficiency and heavier placentas in sheep after suppressing CXCL12/CXCR4 signaling during implantation

RL Ashley, EM Trigo, JM Ervin - Biology of Reproduction, 2023 - academic.oup.com
During implantation, trophoblast cell invasion and differentiation is predominantly important
to achieving proper placental formation and embryonic development. The chemokine, CXC …

Maternal nutrient restriction and over-feeding during gestation alter expression of key factors involved in placental development and vascularization

SA Reed, R Ashley, G Silver, C Splaine… - Journal of animal …, 2022 - academic.oup.com
Poor maternal nutrition can negatively affect fetal and placental growth and development.
However, the mechanism (s) that contribute to altered placenta growth and function are not …

Transcriptome Comparison of Chorion-Attached and Non-chorion-attached Endometrium in Mid-gestation of Rabbit

X Mei, L Xu, Y Ren, M Yu, L Kuang, C Li… - Frontiers in Veterinary …, 2022 - frontiersin.org
Background The chorion from the placenta is directly attached to the endometrium (CA) after
embryo implantation while some parts of the endometrium are not chorion-attached (NCA) …

Impacts to the Insulin-Like Growth Factor System in Placenta and Fetal Liver at Mid and Late Gestation in an Ovine Model of Placental Insufficiency

KM Mason - 2023 - search.proquest.com
Improper placentation is the root cause of many fetal disease states that can lead to fetal
morbidity. This study aims to further characterize the importance of chemokine receptor 4 …

[PDF][PDF] Identification of Key Candidate Genes and Pathways in Preterm Birth by Integrated Bioinformatical Analysis J, 2

WF Zheng, P Peng, X Yuan, J Qin… - … Health Care and, 2021 - pdfs.semanticscholar.org
Background: Preterm birth (PTB) is a primary cause of neonatal morbidity and mortality, the
pathogenic mechanisms of PTB still remain largely unexplored. In the present study, we …