New trends in the quality control of enantiomeric drugs: quality by design-compliant development of chiral capillary electrophoresis methods

S Orlandini, G Hancu, ZI Szabó, A Modroiu, LA Papp… - Molecules, 2022 - mdpi.com
Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is
commonly used in the enantioseparation and chiral purity control of pharmaceuticals from …

Advances in the use of cyclodextrins as chiral selectors in capillary electrokinetic chromatography: fundamentals and applications

Q Zhu, GKE Scriba - Chromatographia, 2016 - Springer
Capillary electrokinetic chromatography is generally recognized as a versatile and robust
capillary electromigration technique for the separation of enantiomers. In this mode, one or …

Critical review of reports on impurity and degradation product profiling in the last decade

S Görög - TrAC Trends in Analytical Chemistry, 2018 - Elsevier
Drug impurity and degradation profiling mean the detection, structure elucidation and
quantitative determination of impurities and degradation products in bulk drug materials and …

Application of experimental design methodologies in the enantioseparation of pharmaceuticals by capillary electrophoresis: A review

G Hancu, S Orlandini, LA Papp, A Modroiu, R Gotti… - Molecules, 2021 - mdpi.com
Chirality is one of the major issues in pharmaceutical research and industry. Capillary
electrophoresis (CE) is an interesting alternative to the more frequently used …

Negatively charged cyclodextrins: Synthesis and applications in chiral analysis-A review

C Guo, Y Xiao - Carbohydrate Polymers, 2021 - Elsevier
The negatively charged cyclodextrins (CDs) play an important role in chiral analysis due to
the additional electrostatic effect beyond the host-guest inclusion, especially in …

Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

R Řemínek, F Foret - Electrophoresis, 2021 - Wiley Online Library
Capillary electrophoresis represents a promising technique in the field of pharmaceutical
analysis. The presented review provides a summary of capillary electrophoretic methods …

Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris (3-chloro-4-methylphenylcarbamate) column under revered-phase …

LA Papp, G Hancu, ZI Szabó - Journal of Pharmaceutical and Biomedical …, 2023 - Elsevier
A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous
determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) …

Enantiomeric determination of drugs in pharmaceutical formulations and biological samples by electrokinetic chromatography

N Casado, J Valimaña-Traverso… - Critical reviews in …, 2020 - Taylor & Francis
Chirality is a relevant issue in the pharmaceutical field due to the different biological activity
that enantiomers of a chiral drug can show. In fact, the desired biological or pharmaceutical …

Chiral selectors in CE: Recent development and applications (mid‐2014 to mid‐2016)

IJ Stavrou, EA Agathokleous… - …, 2017 - Wiley Online Library
This report, which is a sequence of a series of reviews, records the most important chiral
selectors (CSs) applied in CE. It highlights the CSs that were used during the period 2014 to …

Synthesis and application of ionic liquid functionalized β-cyclodextrin, mono-6-deoxy-6-(4-amino-1, 2, 4-triazolium)-β-cyclodextrin chloride, as chiral selector in …

J Li, T Yu, G Xu, Y Du, Z Liu, Z Feng, X Yang… - … of Chromatography A, 2018 - Elsevier
Recently, ionic liquids (ILs) functionalized cyclodextrins (CDs) have attracted more and more
attention in the fields of enantioseparation. In this study, a novel IL amino triazolium …