Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain
Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …
The impact of human hyperekplexia mutations on glycine receptor structure and function
A Bode, JW Lynch - Molecular brain, 2014 - Springer
Hyperekplexia is a rare neurological disorder characterized by neonatal hypertonia,
exaggerated startle responses to unexpected stimuli and a variable incidence of apnoea …
exaggerated startle responses to unexpected stimuli and a variable incidence of apnoea …
[HTML][HTML] Functional and biochemical consequences of disease variants in neurotransmitter transporters: a special emphasis on folding and trafficking deficits
Neurotransmitters, such as γ-aminobutyric acid, glutamate, acetyl choline, glycine and the
monoamines, facilitate the crosstalk within the central nervous system. The designated …
monoamines, facilitate the crosstalk within the central nervous system. The designated …
Neurobiology of glycine transporters: From molecules to behavior
BL Marques, OC Oliveira-Lima, GA Carvalho… - Neuroscience & …, 2020 - Elsevier
Abstract Glycine transporters (GlyTs) are Na+/Cl−-dependent neurotransmitter transporters,
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …
The creatine transporter unfolded: a knotty premise in the cerebral creatine deficiency syndrome
CV Farr, A El-Kasaby, M Freissmuth… - Frontiers in Synaptic …, 2020 - frontiersin.org
Creatine provides cells with high-energy phosphates for the rapid reconstitution of
hydrolyzed adenosine triphosphate. The eponymous creatine transporter (CRT1/SLC6A8) …
hydrolyzed adenosine triphosphate. The eponymous creatine transporter (CRT1/SLC6A8) …
Impaired glycine receptor trafficking in neurological diseases
N Schaefer, V Roemer, D Janzen… - Frontiers in molecular …, 2018 - frontiersin.org
Ionotropic glycine receptors (GlyRs) enable fast synaptic neurotransmission in the adult
spinal cord and brainstem. The inhibitory GlyR is a transmembrane glycine-gated chloride …
spinal cord and brainstem. The inhibitory GlyR is a transmembrane glycine-gated chloride …
[HTML][HTML] Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease
Startle disease is a rare, potentially fatal neuromotor disorder characterized by exaggerated
startle reflexes and hypertonia in response to sudden unexpected auditory, visual or tactile …
startle reflexes and hypertonia in response to sudden unexpected auditory, visual or tactile …
A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter
Mutations in the C terminus of the serotonin transporter (SERT) disrupt folding and export
from the endoplasmic reticulum. Here we examined the hypothesis that a cytosolic heat …
from the endoplasmic reticulum. Here we examined the hypothesis that a cytosolic heat …
SLC6 transporter folding diseases and pharmacochaperoning
The human genome encodes 19 genes of the solute carrier 6 (SLC6) family; non-
synonymous changes in the coding sequence give rise to mutated transporters, which are …
synonymous changes in the coding sequence give rise to mutated transporters, which are …
How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers
Point mutations in the coding sequence for solute carrier 6 (SLC6) family members result in
clinically relevant disorders, which are often accounted for by a loss-of-function phenotype …
clinically relevant disorders, which are often accounted for by a loss-of-function phenotype …