The concept of metabolic health, particularly in obesity, has attracted a lot of attention in the
scientific community, and is being increasingly used to determine the risk of cardiovascular …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Obesity-associated morbidity is exacerbated by abdominal obesity, which can be measured
as the waist-to-hip ratio adjusted for the body mass index (WHRadjBMI). Here we identify …

We identified apilimod as an antiproliferative compound by high-throughput screening of
clinical-stage drugs. Apilimod exhibits exquisite specificity for phosphatidylinositol-3 …

The endocytic network comprises a series of interconnected tubulo-vesicular membranous
compartments that together regulate various sorting and signalling events. Although it is …

Intestinal stem cell (ISC) is a promising therapeutic target for inflammatory bowel disease.
Cholesterol availability is critical for ISC stemness. Low plasma cholesterol is a typical …

Although numerous polymorphisms have been associated with inflammatory bowel disease
(IBD), identifying the function of these genetic factors has proved challenging. Here we …

The phosphoinositides (PIs) function as efficient and finely tuned switches that control the
assembly–disassembly cycles of complex molecular machineries with key roles in …

Abstract Chaperone-mediated autophagy (CMA), one of the degradation pathways of
proteins, is highly selective to substrates that have KFERQ-like motif. In this process, the …