Innate lymphoid cells (ILCs) and natural killer (NK) cells have garnered considerable
interest due to their unique functional properties in immune defense and tissue homeostasis …

Innate lymphoid cell (ILCs) subsets differentially populate various barrier and non-barrier
tissues, where they play important roles in tissue homeostasis and tissue-specific responses …

Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity
and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic …

Sensory axons degenerate following separation from their cell body, but partial injury to
peripheral nerves may leave the integrity of damaged axons preserved. We show that an …

Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral
infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory …

Group 1 innate lymphoid cells (ILCs) comprising circulating natural killer (cNK) cells and
tissue-resident ILC1s are critical for host defense against pathogens and tumors. Despite a …

Recent single-cell RNA-sequencing studies have suggested that cells follow continuous
transcriptomic trajectories in an asynchronous fashion during development. However …

Blood cells are continually produced from a pool of progenitors that derive from
hematopoietic stem cells (HSCs). In vertebrates, the hematopoietic system develops from …

Natural killer (NK) cells are a critical component of the innate immune system. However,
their ontogenic origin has remained unclear. Here, we report that NK cell potential first arises …

The human fetal immune system is naturally exposed to maternal allogeneic cells, maternal
antibodies, and pathogens. As such, it is faced with a considerable challenge with respect to …