Temozolomide (TMZ) is a methylating agent used as the first-line drug in the chemotherapy
of glioblastomas. However, cancer cells eventually acquire resistance, necessitating the …

PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in
genome stability. Human PIF1 (hPIF1) is poorly understood, but its functions can become …

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally. It's recognized
that the molecular subtype of CRC, characterized by mismatch repair deficiency (dMMR) or …

Despite their widespread impact on human health, there are no approved drugs for
combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 …

A future perspective on the “history of drug discovery” would more than likely characterize
the 20th century (1901− 1999) as one of the most significant collections of decades with …

In this issue, Picco and colleagues provide further evidence that WRN inhibitors are
synthetically lethal in microsatellite instability-high (MSI-H) cancers and function by blocking …

Genomic technologies have led to massive gains in our understanding of human gene
function and disease relevance. Chemical biologists are a primary beneficiary of this …

Werner syndrome RecQ helicase (WRN), a member of the RecQ helicase family, has
recently been identified as a synthetic lethal target in microsatellite instability (MSI) tumors …

Molecular glues that engage protein complexes have transformed the study of cell biology
and have had a direct impact on clinical oncology. However, the identification of new glue …

Targeting cancer-specific vulnerabilities through synthetic lethality (SL) is an emerging
paradigm in precision oncology. A SL strategy based on PARP inhibitors has demonstrated …