Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in
regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and …

Protozoan diseases cause great harm in animal husbandry and require human-provided
medical treatment. Protozoan infection can induce changes in cyclooxygenase-2 (COX-2) …

Currently, there is no known cause for ulcerative colitis (UC), an inflammatory bowel disease
that is difficult to treat. This assay aimed to investigate the protective effects and mechanisms …

Background Cerebral malaria (CM) is a neuropathology which remains one of the deadliest
forms of malaria among African children. The kinetics of the pathophysiological mechanisms …

Severe malarial anemia (SMA; hemoglobin [Hb]< 5.0 g/dL) is a leading global cause of
morbidity and mortality among children residing in Plasmodium falciparum transmission …

Abstract Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-
2)] induces the production of prostaglandins as part of the host-immune response to …

In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood
cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis …

The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-
threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such …

Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity
and mortality in children. The genetic factors that influence development of SMA and …

In holoendemic Plasmodium falciparum transmission regions, malarial anemia is a leading
cause of childhood morbidity and mortality. Identifying biomarkers of malaria disease …