Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

Over the past decade, epigenetic clocks have emerged as powerful machine learning tools,
not only to estimate chronological and biological age but also to assess the efficacy of anti …

Aging and cancer share common cellular hallmarks, including cellular senescence, genomic
instability, and abnormal cell death and proliferation, highlighting potential areas for …

Telomerase reverse transcriptase (TERT), a critical player in cellular immortalization, has
emerged as a focal point of investigation due to its frequent promoter mutations in various …

Aging is the result of a complex interplay of physical, environmental, and social factors,
leading to an increased prevalence of chronic age-related diseases that burden health and …

Background/Objectives: Telomerase reverse transcriptase (TERT) is the catalytic subunit of
the telomerase enzyme responsible for telomere length maintenance and is an important …

Organoids have emerged as transformative tools in biomedical research, renowned for their
ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted …

Disordered glucose and lipid metabolism, coupled with disturbed mitochondrial
bioenergetics, are pivotal in the initiation and development of diabetic kidney disease …

The ageing process involves a gradual decline of chromosome integrity throughout an
organism's lifespan. Telomeres are protective DNA-protein complexes that cap the ends of …

While previous research has demonstrated the therapeutic efficacy of telomerase reverse
transcriptase (TERT) overexpression using adeno‐associated virus and cytomegalovirus …