High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research

AJ Michels, B Frei - Nutrients, 2013 - mdpi.com
Research progress to understand the role of vitamin C (ascorbic acid) in human health has
been slow in coming. This is predominantly the result of several flawed approaches to study …

Ascorbate is a primary antioxidant in mammals

J Fujii, T Osaki, T Bo - Molecules, 2022 - mdpi.com
Ascorbate (vitamin C in primates) functions as a cofactor for a number of enzymatic reactions
represented by prolyl hydroxylases and as an antioxidant due to its ability to donate …

The double faced role of xanthine oxidoreductase in cancer

M Chen, L Meng - Acta Pharmacologica Sinica, 2022 - nature.com
Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two
steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid …

Biology and diseases of mice

MT Whary, N Baumgarth, JG Fox… - Laboratory animal …, 2015 - Elsevier
Today's laboratory mouse, Mus musculus, has its origins as the 'house mouse'of North
America and Europe. Beginning with mice bred by mouse fanciers, laboratory stocks …

Vitamin C and lifespan in model organisms

K Pallauf, JK Bendall, C Scheiermann… - Food and Chemical …, 2013 - Elsevier
The process of ageing has been repeatedly associated with increasing oxidative damage
which has led to the hypothesis that reducing oxidative stress through antioxidant dietary …

N‐Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs

EA Herrera, F Cifuentes‐Zúñiga… - The Journal of …, 2017 - Wiley Online Library
Key points Intrauterine growth restriction (IUGR) is associated with vascular dysfunction,
oxidative stress and signs of endothelial epigenetic programming of the umbilical vessels …

[HTML][HTML] Vitamin C–a scoping review for Nordic Nutrition Recommendations 2023

J Lykkesfeldt, AC Carr - Food & Nutrition Research, 2023 - ncbi.nlm.nih.gov
Vitamin C has multiple metabolic functions in the body, but the available information on the
exact relationship between these functions and the intake necessary to maintain them is …

Examining the polyphenol content, antioxidant activity and fatty acid composition of twenty-one different wastes of fruits, vegetables, oilseeds and beverages

S Kuppusamy, K Venkateswarlu, M Megharaj - SN Applied Sciences, 2020 - Springer
One of the most abundantly available, cost-effective valuable resources that are of all-time
concern for minimization and economical re-utilization is food waste, and quantifying the …

Vitamin C differentially impacts the serum proteome profile in female and male mice

L Aumailley, S Bourassa, C Gotti, A Droit… - Journal of Proteome …, 2021 - ACS Publications
A suboptimal blood vitamin C (ascorbate) level increases the risk of several chronic
diseases. However, the detection of hypovitaminosis C is not a simple task, as ascorbate is …