Safety and efficacy of adeno-associated viral gene therapy in patients with retinal degeneration: a systematic review and meta-analysis
Purpose: This systematic review evaluates the safety and efficacy of ocular gene therapy
using adeno-associated virus (AAV). Methods: MEDLINE, Embase, Cochrane Central …
using adeno-associated virus (AAV). Methods: MEDLINE, Embase, Cochrane Central …
The role of subretinal injection in ophthalmic surgery: therapeutic agent delivery and other indications
D Tripepi, A Jalil, N Ally, M Buzzi, G Moussa… - International Journal of …, 2023 - mdpi.com
Subretinal injection is performed in vitreoretinal surgery with two main aims, namely, the
subretinal delivery of therapeutic agents and subretinal injection of fluid to induce a …
subretinal delivery of therapeutic agents and subretinal injection of fluid to induce a …
Outcomes and Adverse Effects of Voretigene Neparvovec Treatment for Biallelic RPE65-Mediated Inherited Retinal Dystrophies in a Cohort of Patients from a Single …
P Kiraly, CL Cottriall, LJ Taylor, JK Jolly… - Biomolecules, 2023 - mdpi.com
Our study evaluated the morphological and functional outcomes, and the side effects, of
voretigene neparvovec (VN) gene therapy for RPE65-mediated inherited retinal dystrophies …
voretigene neparvovec (VN) gene therapy for RPE65-mediated inherited retinal dystrophies …
Voretigene neparvovec gene therapy in clinical practice: treatment of the first two Italian pediatric patients
F Testa, P Melillo, M Della Corte… - … Vision Science & …, 2021 - tvst.arvojournals.org
Purpose: To present visual outcomes of the first two Italian patients with RPE65-related
inherited retinal dystrophy (RPE65-IRD) treated with voretigene neparvovec (VN). Methods …
inherited retinal dystrophy (RPE65-IRD) treated with voretigene neparvovec (VN). Methods …
Intravitreal air tamponade after AAV2 subretinal injection modifies retinal EGFP distribution
JB Ducloyer, V Pichard, M Mevel, A Galy… - … Therapy Methods & …, 2023 - cell.com
The subretinal injection protocol for the only approved retinal gene therapy (voretigene
neparvovec-rzyl) includes air tamponade at the end of the procedure, but its effects on the …
neparvovec-rzyl) includes air tamponade at the end of the procedure, but its effects on the …
[HTML][HTML] Voretigene Neparvovec for the Treatment of RPE65-associated Retinal Dystrophy: Consensus and Recommendations from the Korea RPE65-IRD Consensus …
Mutations in the RPE65 gene, associated with Leber congenital amaurosis, early-onset
severe retinal dystrophy, and retinitis pigmentosa, gained growing attention since gene …
severe retinal dystrophy, and retinitis pigmentosa, gained growing attention since gene …
[HTML][HTML] Objective Outcomes to Evaluate Voretigene Neparvovec Treatment Effects in Clinical Practice
Purpose To assess the efficacy of voretigene neparvovec (VN) treatment by objective
fixation stability and chromatic pupillometry testing in clinical practice. Design Retrospective …
fixation stability and chromatic pupillometry testing in clinical practice. Design Retrospective …
La thérapie génique des rétinites pigmentaires héréditaires
JB Ducloyer, G Le Meur, T Cronin, O Adjali… - médecine …, 2020 - medecinesciences.org
Les rétinites pigmentaires, ou dystrophies rétiniennes héréditaires, sont des maladies
dégénératives cécitantes d'origine génétique. La thérapie génique est une approche …
dégénératives cécitantes d'origine génétique. La thérapie génique est une approche …