Dock-family exchange factors in cell migration and disease
Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac
and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 …
and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 …
Targeting the small GTPase superfamily through their regulatory proteins
The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …
[HTML][HTML] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …
Podosome organization drives osteoclast-mediated bone resorption
D Georgess, I Machuca-Gayet, A Blangy… - Cell adhesion & …, 2014 - Taylor & Francis
Osteoclasts are the cells responsible for physiological bone resorption. A specific
organization of their most prominent cytoskeletal structures, podosomes, is crucial for the …
organization of their most prominent cytoskeletal structures, podosomes, is crucial for the …
Targeting Rac and Cdc42 GEFs in metastatic cancer
MDM Maldonado, JI Medina, L Velazquez… - Frontiers in cell and …, 2020 - frontiersin.org
The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …
Apoptotic cell clearance components in inflammatory arthritis
K Schneider, S Arandjelovic - Immunological Reviews, 2023 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovial joints that
affects~ 1% of the human population. Joint swelling and bone erosion, hallmarks of RA …
affects~ 1% of the human population. Joint swelling and bone erosion, hallmarks of RA …
Insights into the biological functions of Dock family guanine nucleotide exchange factors
Rho GTPases play key regulatory roles in many aspects of embryonic development,
regulating processes such as differentiation, proliferation, morphogenesis, and migration …
regulating processes such as differentiation, proliferation, morphogenesis, and migration …
The regulation of osteoclast function and bone resorption by small GTPases
C Itzstein, FP Coxon, MJ Rogers - Small GTPases, 2011 - Taylor & Francis
Osteoclasts are multinucleated cells that are responsible for resorption of bone, and
increased activity of these cells is associated with several common bone diseases, including …
increased activity of these cells is associated with several common bone diseases, including …
The osteoclast cytoskeleton–current understanding and therapeutic perspectives for osteoporosis
A Blangy, G Bompard, D Guerit, P Marie… - Journal of cell …, 2020 - journals.biologists.com
Osteoclasts are giant multinucleated myeloid cells specialized for bone resorption, which is
essential for the preservation of bone health throughout life. The activity of osteoclasts relies …
essential for the preservation of bone health throughout life. The activity of osteoclasts relies …