Background Ovarian cancer is the main cause of gynecological cancer-associated death.
However, 5-year survival rates differ dramatically between the five main ovarian carcinoma …

Background Neural stem cell (NSC)-based therapies hold great promise for treating
diseases of the central nervous system (CNS). However, several fundamental problems still …

Background Tertiary lymphoid structures (TLS) have an effect on hepatocellular carcinoma
(HCC), but the underlying mechanism remains to be elucidated. Methods Intratumoral TLS …

Aberrant activation of NOTCH1 signaling plays a vital role in the pathogenesis of T-cell
acute lymphoblastic leukemia (T-ALL). Yet the molecular events downstream of NOTCH1 …

T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with
complicated heterogeneity. Although expression profiling reveals common elevated genes …

Gene function can be described using various measures. We integrated association studies
of three types of omics data to provide insights into the pathophysiology of subclinical …

FAXDC2 (fatty acid hydroxylase domain containing 2) is a member of the fatty acid
hydroxylase superfamily. Given the important role of fatty acids in megakaryocytes, we have …

Introduction Obesity is associated with a plethora of health complications, including
increased susceptibility to infections or decreased vaccine efficacy, partly due to …

The Human Proteome Project (HPP) consortium aims to functionally characterize the dark
proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have …

The proteasome is a protein-degrading molecular complex that is necessary for protein
homeostasis and various biological functions, including cell cycle regulation, signal …