When stiffness matters: mechanosensing in heart development and disease

R Gaetani, EA Zizzi, MA Deriu, U Morbiducci… - Frontiers in Cell and …, 2020 - frontiersin.org
During embryonic morphogenesis, the heart undergoes a complex series of cellular
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …

Lattice-Boltzmann modelling for inertial particle microfluidics applications-a tutorial review

B Owen, K Kechagidis, SR Bazaz… - … in Physics: X, 2023 - Taylor & Francis
Inertial particle microfluidics (IPMF) is an emerging technology for the manipulation and
separation of microparticles and biological cells. Since the flow physics of IPMF is complex …

Crosslinking of fibrous hydrogels

DC Schoenmakers, AE Rowan, PHJ Kouwer - Nature communications, 2018 - nature.com
In contrast to most synthetic hydrogels, biological gels are made of fibrous networks. This
architecture gives rise to unique properties, like low concentration, high porosity gels with a …

Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling

TH Kim, NK Gill, KD Nyberg, AV Nguyen… - Journal of cell …, 2016 - journals.biologists.com
Invasion by cancer cells is a crucial step in metastasis. An oversimplified view in the
literature is that cancer cells become more deformable as they become more invasive. β …

Regulation of actin bundle mechanics and structure by intracellular environmental factors

N Castaneda, J Park, EH Kang - Frontiers in physics, 2021 - frontiersin.org
The mechanical and structural properties of actin cytoskeleton drive various cellular
processes, including structural support of the plasma membrane and cellular motility. Actin …

Morphological transformation and force generation of active cytoskeletal networks

TC Bidone, W Jung, D Maruri, C Borau… - PLoS computational …, 2017 - journals.plos.org
Cells assemble numerous types of actomyosin bundles that generate contractile forces for
biological processes, such as cytokinesis and cell migration. One example of contractile …

Charge-dependent interactions of monomeric and filamentous actin with lipid bilayers

CFE Schroer, L Baldauf, L van Buren… - Proceedings of the …, 2020 - National Acad Sciences
The cytoskeletal protein actin polymerizes into filaments that are essential for the
mechanical stability of mammalian cells. In vitro experiments showed that direct interactions …

Probing eukaryotic cell mechanics via mesoscopic simulations

K Lykov, Y Nematbakhsh, M Shang… - PLoS computational …, 2017 - journals.plos.org
Cell mechanics has proven to be important in many biological processes. Although there is
a number of experimental techniques which allow us to study mechanical properties of cell …

Biomechanics of cells and subcellular components: a comprehensive review of computational models and applications

C Wang, S Li, AS Ademiloye… - International Journal for …, 2021 - Wiley Online Library
Cells are a fundamental structural, functional and biological unit for all living organisms. Up
till now, considerable efforts have been made to study the responses of single cells and …

Insights into the cooperative nature of ATP hydrolysis in actin filaments

HH Katkar, A Davtyan, AEP Durumeric, GM Hocky… - Biophysical journal, 2018 - cell.com
Actin filaments continually assemble and disassemble within a cell. Assembled filaments"
age" as a bound nucleotide ATP within each actin subunit quickly hydrolyzes followed by a …