Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …

Immune response and immunopathology during toxoplasmosis

CD Dupont, DA Christian, CA Hunter - Seminars in immunopathology, 2012 - Springer
Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is
able to infect any warm-blooded vertebrate host. In addition to its importance to public …

Interleukin-10-deficient mice develop chronic enterocolitis

R Kühn, J Löhler, D Rennick, K Rajewsky, W Müller - Cell, 1993 - cell.com
Summary Interleukin-10 (IL-10) affects the growth and differentiation of many hemopoietic
cells in vitro; in particular, it is a potent suppressor of macrophage and T cell functions. In IL …

Development of TH1 CD4+ T Cells Through IL-12 Produced by Listeria-Induced Macrophages

CS Hsieh, SE Macatonia, CS Tripp, SF Wolf, A O'Garra… - Science, 1993 - science.org
Development of the appropriate CD4+ T helper (TH) subset during an immune response is
important for disease resolution. With the use of naive, ovalbumin-specific αβ T cell receptor …

1α, 25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells

A Boonstra, FJ Barrat, C Crain, VL Heath… - The Journal of …, 2001 - journals.aai.org
Abstract 1α, 25-Dihydroxyvitamin D3 (vitD3) is an immunoregulatory hormone with
beneficial effects on Th1 mediated autoimmune diseases. Although the inhibitory effects of …

[PDF][PDF] Indexing and exploiting a discourse history to generate context-sensitive explanations

JD Moore - Human Language Technology: Proceedings of a …, 1993 - aclanthology.org
ABSTRACT A slriking difference between the interactions that students have with human
tutors and those they have with computer-based instruction systems is that human tutors …

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases

SE Swedo, HL Leonard, M Garvey… - Obsessive …, 2022 - taylorfrancis.com
Objective: The purpose of this study was to describe the clinical characteristics of a novel
group of patients with obsessive-compulsive disorder (OCD) and tic disorders, designated …

Immune regulation by helminth parasites: cellular and molecular mechanisms

RM Maizels, M Yazdanbakhsh - Nature Reviews Immunology, 2003 - nature.com
Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Interleukin-18

JA Gracie, SE Robertson… - Journal of Leucocyte …, 2003 - academic.oup.com
Abstract Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily,
is now recognized as an important regulator of innate and acquired immune responses. IL …