Obesity and bone: a complex relationship

G Rinonapoli, V Pace, C Ruggiero, P Ceccarini… - International journal of …, 2021 - mdpi.com
There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Q Chen, P Shou, C Zheng, M Jiang, G Cao… - Cell Death & …, 2016 - nature.com
Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Heterogeneity of adipose tissue in development and metabolic function

T Schoettl, IP Fischer, S Ussar - Journal of Experimental …, 2018 - journals.biologists.com
Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These …

Quantitative MRI and spectroscopy of bone marrow

DC Karampinos, S Ruschke… - Journal of Magnetic …, 2018 - Wiley Online Library
Bone marrow is one of the largest organs in the human body, enclosing adipocytes,
hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal …

Obesity and bone health: a complex link

J Hou, C He, W He, M Yang, X Luo, C Li - Frontiers in cell and …, 2020 - frontiersin.org
So far, the connections between obesity and skeleton have been extensively explored, but
the results are inconsistent. Obesity is thought to affect bone health through a variety of …

The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity

D Ali, M Tencerova, F Figeac, M Kassem… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …

High‐fat diet–induced obesity promotes expansion of bone marrow adipose tissue and impairs skeletal stem cell functions in mice

M Tencerova, F Figeac, N Ditzel… - Journal of Bone and …, 2018 - academic.oup.com
Obesity represents a risk factor for development of insulin resistance and type 2 diabetes. In
addition, it has been associated with increased adipocyte formation in the bone marrow …

Clinical implications of bone marrow adiposity

AG Veldhuis‐Vlug, CJ Rosen - Journal of internal medicine, 2018 - Wiley Online Library
Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …

Marrow fat and bone—new perspectives

PK Fazeli, MC Horowitz, OA MacDougald… - The Journal of …, 2013 - academic.oup.com
Context: There is growing interest in the relationship between bone mineral density, bone
strength, and fat depots. Marrow adipose tissue, a well-established component of the …

Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures

JM Patsch, X Li, T Baum, SP Yap… - Journal of bone and …, 2013 - academic.oup.com
The goal of this magnetic resonance (MR) imaging study was to quantify vertebral bone
marrow fat content and composition in diabetic and nondiabetic postmenopausal women …