Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

The combination of pharmacology and transcranial magnetic stimulation to study the effects
of drugs on TMS-evoked EMG responses (pharmaco-TMS-EMG) has considerably improved …

Changing the strength of connections between neurons is widely assumed to be the
mechanism by which memory traces are encoded and stored in the central nervous system …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

1962). Indeed, the two membranes are separated by a Calcium plays an important role in
regulating a great fuzzy material with a distinct periodicity reminiscent of variety of neuronal …

Long-term potentiation (LTP) is a synaptic enhancement that follows brief, high-frequency
electrical stimulation in the hippocampus and neocortex. Recent evidence suggests that …

PARTIALLY synchronous 40-Hz oscillations of cortical neurons have been implicated in
cognitive function. Specifically, coherence of these oscillations between different parts of the …

Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been
considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and …

Shank is a recently described family of postsynaptic proteins that function as part of the
NMDA receptor–associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]) …

Long-term potentiation in the CA1 region of the hippocampus is the most extensively studied
model of activity-dependent synaptic plasticity in the mammalian brain. Its induction normally …