Viral innate immune evasion and the pathogenesis of emerging RNA virus infections
T Nelemans, M Kikkert - Viruses, 2019 - mdpi.com
Positive-sense single-stranded RNA (+ ssRNA) viruses comprise many (re-) emerging
human pathogens that pose a public health problem. Our innate immune system and, in …
human pathogens that pose a public health problem. Our innate immune system and, in …
MicroRNA regulation of RNA virus replication and pathogenesis
DW Trobaugh, WB Klimstra - Trends in molecular medicine, 2017 - cell.com
microRNAs (miRNAs) are non-coding RNAs that regulate many processes within a cell by
manipulating protein levels through direct binding to mRNA and influencing translation …
manipulating protein levels through direct binding to mRNA and influencing translation …
[HTML][HTML] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …
The role of interleukin 6 during viral infections
L Velazquez-Salinas, A Verdugo-Rodriguez… - Frontiers in …, 2019 - frontiersin.org
Our recently published research on the characterization of vesicular stomatitis virus (VSV)
pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the …
pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the …
Pharmacological activation of STING blocks SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic, resulting in millions of infections and deaths with few effective interventions …
pandemic, resulting in millions of infections and deaths with few effective interventions …
[HTML][HTML] In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic. Understanding of the RNA virus and its …
coronavirus disease 2019 (COVID-19) pandemic. Understanding of the RNA virus and its …
Detection of microbial infections through innate immune sensing of nucleic acids
Microbial infections are recognized by the innate immune system through germline-encoded
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …
Global aspects of viral glycosylation
I Bagdonaite, HH Wandall - Glycobiology, 2018 - academic.oup.com
Enveloped viruses encompass some of the most common human pathogens causing
infections of different severity, ranging from no or very few symptoms to lethal disease as …
infections of different severity, ranging from no or very few symptoms to lethal disease as …
Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro
Y Wu, Q Liu, J Zhou, W Xie, C Chen, Z Wang, H Yang… - Cell discovery, 2017 - nature.com
Type I interferon (IFN) serves as the first line of defense against invading pathogens.
Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV …
Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV …